180624-08-2Relevant articles and documents
Total synthesis of kealiiquinone: the regio-controlled strategy for accessing its 1-methyl-4-arylbenzimidazolone core
Ramadoss, Velayudham,Alonso-Castro, Angel J.,Campos-Xolalpa, Nimsi,Ortiz-Alvarado, Rafael,Yahuaca-Juárez, Berenice,Solorio-Alvarado, César R.
, p. 30761 - 30776 (2018)
A practical, concise and straightforward total synthesis of kealiiquinone 1, a naphtho[2,3-d]imidazole alkaloid obtained from the Micronesian marine sponge Leucetta sp. was accomplished. The squaric acid chemistry to construct the 1,4-quinoid ring and the regioselective N-methylation through a benzo[c][1,2,5]selenadiazolium heterocycle are the key features in this report. The full details of the representative approaches involving the different attempted synthetic strategies are also presented. Finally a successful total synthesis of this complex secondary metabolite is described.
Anti-osteoporosis compound as well as derivatives, pharmaceutical composition, preparation method and application thereof
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Paragraph 0133-0137, (2021/08/14)
The invention discloses an anti-osteoporosis compound as well as derivatives, a pharmaceutical composition, a preparation method and application thereof. The structure of the compound is shown in a formula (I), the derivatives of the compound relate to an
Preparation method of 3-acetylindole BRPF1 inhibitor and use of 3-acetylindole BRPF1 inhibitor
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Paragraph 0077-0080; 0098; 0099; 0134; 0139; 0140; 0297-0300, (2020/03/03)
The invention relates to a 3-acetylindole compound of a novel structure shown in a formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate or a solvate thereof, a preparation method of the compound, a pharmaceutical composition containing a therapeutically effective dose of the compound, and use thereof as a protein tyrosine kinase inhibitor, especially as a bromine-containing area PHD zinc finger protein 1 (BRPF1) inhibitor, in the prevention or treatment of disease benefited from the inhibition of BRPF1.