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17,21-dihydroxypregn-4-ene-3,20-dione 17,21-di(acetate) is a synthetic steroid derivative and an acetate ester of the hormone progesterone. It is a potent progestogen with a chemical structure that allows for better absorption and prolonged effects in the body.
Used in Hormone Therapy:
17,21-dihydroxypregn-4-ene-3,20-dione 17,21-di(acetate) is used as a hormone therapy agent for the treatment of various hormone-related conditions, such as menstrual disorders, endometriosis, and hormone replacement therapy. Its potent progestogenic activity helps regulate hormonal imbalances and alleviate symptoms associated with these conditions.
Used in Contraceptive Applications:
17,21-dihydroxypregn-4-ene-3,20-dione 17,21-di(acetate) is used as a contraceptive agent in combination with other hormones. Its progestogenic properties contribute to the prevention of ovulation, thereby reducing the chances of pregnancy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 17,21-dihydroxypregn-4-ene-3,20-dione 17,21-di(acetate) is used as an active pharmaceutical ingredient in the development of hormone-related medications. Its acetate form enhances the drug's bioavailability and effectiveness, making it a valuable component in the formulation of various therapeutic products.

1807-15-4

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1807-15-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1807-15-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,0 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1807-15:
(6*1)+(5*8)+(4*0)+(3*7)+(2*1)+(1*5)=74
74 % 10 = 4
So 1807-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C25H34O6/c1-15(26)30-14-22(29)25(31-16(2)27)12-9-21-19-6-5-17-13-18(28)7-10-23(17,3)20(19)8-11-24(21,25)4/h13,19-21H,5-12,14H2,1-4H3/t19-,20+,21+,23+,24+,25+/m1/s1

1807-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name [2-[(8R,9S,10R,13S,14S,17R)-17-acetyloxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

1.2 Other means of identification

Product number -
Other names 17,21-diacetoxy-4-pregnene-3,20-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1807-15-4 SDS

1807-15-4Relevant academic research and scientific papers

TRANSFORMED STEROIDS. 186. USE OF THE DIACETOXYIODOBENZENE-IODINE SYSTEM FOR THE CONVERSION OF EPIMERIC 17-ETHYNYLANDROST-4-EN-17-OL-3-ONES TO PREGNANES

Turuta, A. M.,Vesela, I. V.,Kamernitskii, A. V.,Vlakhov, Rodoslav

, p. 2508 - 2511 (1991)

Epimeric 17-acetoxy-17-ethynylandrost-4-en-3-ones react with diacetoxyiodobenzene and iodine in acetic acid or methanol in an unusual manner to give 17-acetoxy-21,21-diiodo-17-pregn-4-en-3,20-diones, which are then converted to 21-monoiodides and 21-aceta

Lipase-catalyzed preparation of corticosteroid 17α-esters endowed with antiandrogenic activity

Ferraboschi, Patrizia,Mieri, Maria De,Ragonesi, Laura

, p. 4610 - 4612 (2008)

Several 17α-monoesters of cortexolone and its Δ9-derivative are endowed with antiandrogenic activity. Their synthesis can be accomplished by means of a lipase-catalyzed chemoselective alcoholysis of the corresponding 17α,21-diesters.

Cyanohydrin process

-

, (2008/06/13)

Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17α-acyl progesterones.

Simple Route for Elaboration of the Hydroxy-ketone and Dihydroxy-acetone Side-chains of Corticosteroids from 17-Oxo-steroids

Nedelec, Lucien,Torelli, Vesperto,Hardy, Michel

, p. 775 - 777 (2007/10/02)

α-Formylaminoacrylic esters, produced by the condensation of ethyl isocyanoacetate with 17-oxo-steroids have been reduced selectively to give the corresponding alcohols; the latter gave, in high yield, the hydroxyacetyl side-chain on acidic hydrolysis or the dihydroxy-acetone side-chain after appropriate oxidation and hydrolysis.

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