19357-45-0 Usage
Derivation
Synthetic steroid hormone derived from progesterone.
Common use
Progestogen in hormonal contraceptive medications and hormone replacement therapy.
Chemical structure
Pregnane backbone with hydroxyl groups at positions 17 and 21, a ketone group at position 3, and an acetate group at position 17.
Progestogenic activity
Effective in preventing ovulation, thickening cervical mucus to inhibit sperm penetration, and altering the endometrium to prevent implantation of a fertilized egg.
Pharmaceutical research
Used in pharmaceutical research for the development of new medications.
Reference standard
Utilized as a reference standard in analytical chemistry for the identification and quantification of related compounds.
Mechanism of action
Binds to progesterone receptors in target tissues, leading to the modulation of gene expression and the regulation of various physiological processes.
Side effects
Potential side effects may include headaches, breast tenderness, mood changes, and irregular bleeding, among others.
Contraindications
Not recommended for individuals with a history of blood clots, liver disease, or certain types of cancer.
Dosage
Dosage varies depending on the specific medication and the individual's medical needs, as prescribed by a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 19357-45-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,3,5 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19357-45:
(7*1)+(6*9)+(5*3)+(4*5)+(3*7)+(2*4)+(1*5)=130
130 % 10 = 0
So 19357-45-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H32O5/c1-14(25)28-23(20(27)13-24)11-8-19-17-5-4-15-12-16(26)6-9-21(15,2)18(17)7-10-22(19,23)3/h12,17-19,24H,4-11,13H2,1-3H3/t17-,18+,19+,21+,22+,23+/m1/s1
19357-45-0Relevant articles and documents
Lipase-catalyzed preparation of corticosteroid 17α-esters endowed with antiandrogenic activity
Ferraboschi, Patrizia,Mieri, Maria De,Ragonesi, Laura
, p. 4610 - 4612 (2008/09/21)
Several 17α-monoesters of cortexolone and its Δ9-derivative are endowed with antiandrogenic activity. Their synthesis can be accomplished by means of a lipase-catalyzed chemoselective alcoholysis of the corresponding 17α,21-diesters.