180713-44-4

Upstream product

• 59868-79-0 1,3-dihydroisobenzofuran-1-ol 
• 3282-30-2 pivaloyl chloride 
• 138459-91-3 3-pivaloyl-1,3-thiazolidine-2-thione 
• 341519-79-7 2-hydroxymethylbenzyl pivalate 

Downstream Products

• 341519-80-0 2-(1-hydroxy-2-propynyl)benzyl pivalate 
• 341519-82-2 2,2-dimethyl-propionic acid 2-{4-(tert-butyl-dimethyl-silanyl)-1-[3-hydroxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzyl ester 
• 341519-91-3 2,2-dimethyl-propionic acid 2-{4-(tert-butyl-dimethyl-silanyl)-1-[3-methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzyl ester 
• 341519-85-5 2-{4-(tert-butyl-dimethyl-silanyl)-1-[3-methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid 
• 341519-83-3 (2-{4-(tert-butyl-dimethyl-silanyl)-1-[3-methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-phenyl)-methanol 
• 341519-84-4 2-{4-(tert-butyl-dimethyl-silanyl)-1-[3-methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzaldehyde 
• 341519-86-6 2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid 
• 341519-88-8 2-{(Z)-1-[3-Methoxy-3-(4-methoxy-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid 
• 341519-81-1 2,2-dimethyl-propionic acid 2-[4-(tert-butyl-dimethyl-silanyl)-1-ethynyl-1-hydroxy-but-3-ynyl]-benzyl ester 
• 341519-90-2 2,2-dimethyl-propionic acid 2-[4-(tert-butyl-dimethyl-silanyl)-1-ethynyl-but-1-en-3-ynyl]-benzyl ester 

Relevant academic research and scientific papers

Developments of enediyne model compounds generating biradicals with an enhanced radical character - Regulation of triggering devices

Development of enediyne model compounds generating biradicals with an enhanced radical character is described. These model compounds generate enyne-allenes under mild acidic conditions and the resulting biradicals showed potent DNA cleaving abilities.

Acid-catalyzed cycloaromatization of enediyne model compounds via enyne-allene intermediates

The synthesis of enediyne models which produce dehydrotoluene diradicals preferentially under acidic conditions by means of intramolecular participation of the carboxylic acid is described. To diminish an ionic character of diradicals, an electron-withdrawing group was introduced into the radical-forming carbon of the substrate.

Twisted amides as selective acylating agents for hydroxyl groups under neutral conditions: Models for activated peptides during enzymatic acyl transfer reaction

The highly twisted amide 2 served as a selective acylating agent for diols under neutral conditions. The reaction of primary-secondary diols with 2 led to the corresponding primary alkyl monopivalates. For diols containing alcoholic and phenolic hydroxyl groups, alcoholic hydroxyl groups were selectively acylated under neutral conditions, whereas, the opposite selectivity was observed under basic conditions, similar to the cases using acyl halides or acid anhydrides. Although 1 and 3 were unreactive to alcohols, 5-10 having substituent groups at C-4 were reactive to alcohols to give the corresponding acetates or benzoates.