180748-30-5

Basic information

• Product Name: 4-Chloro-2-pyridinemethanamine
• Synonyms: C-(4-CHLORO-PYRIDIN-2-YL)-METHYLAMINE;(4-CHLOROPYRIDIN-2-YL)METHANAMINE;2-Pyridinemethanamine,4-chloro-(9CI);4-Chloro-2-pyridinemethanamine;2-Aminomethy-4-chloropyridine;2-PyridineMethanaMine, 4-chloro-;(4-Chloropyridin-2-yl)MethanaMine hydrochloride
• CAS NO: 180748-30-5
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• EINECS: 251-156-6
• Product Categories: PYRIDINE;Heterocycle-Pyridine series
• Mol File: 180748-30-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 220 °C
• Flash Point: 87 °C
• Appearance: /
• Density: 1.244
• Vapor Pressure: 0.118mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.42±0.39(Predicted)
• CAS DataBase Reference: 4-Chloro-2-pyridinemethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-pyridinemethanamine(180748-30-5)
• EPA Substance Registry System: 4-Chloro-2-pyridinemethanamine(180748-30-5)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 180748-30-5(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-pyridinemethanamine is a chemical compound with the molecular formula C6H7ClN2. It is a derivative of the heterocyclic compound pyridine, and it contains a chlorine atom and an amine group. This chemical is used in organic synthesis and pharmaceutical research, and it has potential applications in the development of new drugs and agrochemicals. It is also known for its ability to form coordination complexes with transition metals, which has attracted interest in its use as a ligand in metal-mediated catalysis. Additionally, it has been studied for its potential antimicrobial and antifungal properties, making it a valuable compound for various scientific and industrial applications.

InChI:InChI=1/C6H7ClN2/c7-5-1-2-9-6(3-5)4-8/h1-3H,4,8H2

Upstream product

• 13268-51-4 4-chloro-2-pyridyl aldoxime 
• 119396-04-2 4-chloro-2-(chloromethyl)pyridine hydrochloride 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 
• 63071-13-6 4-chloro-2-pyridinecarbaldehyde 
• 13268-51-4 4-chloropicolinaldoxime 
• 98-98-6 2-Picolinic acid 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 10177-21-6 4-chloro-2-chloromethyl pyridine 
• 500716-27-8 2-phthalimidomethyl-4-chloropyridine 

Downstream Products

• 500716-28-9 2-(aminomethyl)-4-(dimethylamino)pyridine 

Relevant articles and documents

Optimization of pentadentate bispidines as bifunctional chelators for 64Cu positron emission tomography (PET)

Pentadentate bispidine ligands (3,7-diazabicyclo[3.3.1]nonanes) are optimized for maximum complex stability and facile functionalization with respect to their coupling to biological vector molecules and/or fluorescence markers for PET (positron emission t

DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX

To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where each X may be the same or different to represent H, Cl, OMe, or, Me, Y is H, a phenyl group, a substituted carbamoyl group or the like).SELECTED DRAWING: None

Design of coordination interaction of Zn(II) complex with oligo-aspartate peptide to afford a high-affinity tag-probe pair

A complementary recognition pair consisting of a genetically encodable peptide tag and a small molecular probe isa powerful tool to specifically label and manipulate a protein ofinterest under biological conditions. In this study, we report the redesign of a tag-probe pair comprising an oligo-aspartate peptide tag (such as DDDD) and a binuclear zinc complex. Isothermal-titration calorimetry screening of binding between the series of peptides and zinc complexes revealed that the binding affinity was largely influenced by subtle changes of the ligand structure of the probe. However, the binding was tolerant to differences of the tag peptide sequence. Of those tested, a pair containing a peptide tag (DDAADD) and a binuclear zinc complex possessing 4-chloropyridines (3-2Zn(II)) showed the strongest binding affinity (Ka = 3.88 × 105 M-1), which was about 10-fold larger than the conventional pair of D4-peptide tag (DDDD) and 1-2Zn(II) containing nonsubstituted pyridines (Ka = 3.73 × 104 M-1). The strong binding of this new complementary recognition pair enabled the rapid covalent labeling of a tag-fused maltose binding protein with a fluorescent zinc complex, demonstrating its potential utility in protein analysis.