1809272-85-2 Usage
Uses
Used in Pharmaceutical Industry:
Acotiamide iMpurity is used as an impurity in the development and production of Acotiamide, an acetylcholinesterase inhibitor. The presence of this impurity is crucial for the effectiveness of Acotiamide in stimulating gastric motility and improving gastric motility dysfunction in rats. It also contributes to the improvement of meal-related symptoms of functional dyspepsia in patients.
Used in Research and Development:
Acotiamide iMpurity is used as a research compound for studying the effects of Acotiamide on gastric motility and functional dyspepsia. This impurity can be utilized in various experimental setups to understand the underlying mechanisms of action and potential side effects of Acotiamide.
Used in Quality Control and Regulatory Compliance:
Acotiamide iMpurity is used in the quality control processes of pharmaceutical manufacturers to ensure the purity and efficacy of Acotiamide. It is essential to monitor and control the levels of this impurity to meet regulatory requirements and maintain the safety and effectiveness of the final product.
Used in Drug Interaction Studies:
Acotiamide iMpurity can be used in drug interaction studies to evaluate the potential effects of Acotiamide when combined with other medications. This information is vital for healthcare providers to make informed decisions about the safe and effective use of Acotiamide in combination with other treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 1809272-85-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,9,2,7 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1809272-85:
(9*1)+(8*8)+(7*0)+(6*9)+(5*2)+(4*7)+(3*2)+(2*8)+(1*5)=192
192 % 10 = 2
So 1809272-85-2 is a valid CAS Registry Number.
1809272-85-2Relevant academic research and scientific papers
Fu, Kai,Yang, Liu,Wang, Qiu-Fen,Zhan, Fu-Xu,Wang, Bin,Yang, Qian,Ma, Zhi-Jia,Zheng, Geng-Xiu
, p. 2006 - 2011 (2015)
A three-step synthesis of acotiamide is described. The agent is marketed in Japan for treatment of patients with functional dyspepsia. We designed a one-pot method to prepare the key intermediate 5a from 2 via an acyl chloride and amide and then reacted w
Preparation method of acotiamide hydrochloride impurity
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Paragraph 0020-0021, (2020/08/02)
The invention discloses a preparation method of an acotiamide hydrochloride impurity. The method comprises the following steps: carrying out acylating chlorination on a raw material 2,4,5-trimethoxybenzoic acid to obtain 2,4,5-trimethoxybenzoyl chloride, and carrying out an amidation reaction on the 2,4,5-trimethoxybenzoyl chloride and 2-amino-4-ethoxycarbonyl-1,3-thiazole to obtain 2-amino-4-ethoxycarbonyl-1,3-thiazole (intermediate 1); hydrolyzing the intermediate 1 with sodium hydroxide to obtain 2-[N-(2,4,5-trimethoxybenzoyl)amino]-4-carboxyl-1,3-thiazole (intermediate 2); and performing an acylating chlorination reaction on the intermediate 2 to obtain an acyl chloride group, performing an amidation reaction on the acyl chloride group and N,N-diisopropylethylenediamine to obtain N-[2-(diisopropylamino)ethyl]-2-[(2,4,5-trimethoxybenzoyl)amino]-4-thiazole formamide (acotiamide), and performing a salt forming reaction on the acotiamide to obtain acotiamide hydrochloride. The preparation method of the acotiamide hydrochloride impurity has the advantages of mild reaction conditions, simple operation, low cost and high yield, and is suitable for industrial production.
