180961-72-2

Basic information

• Product Name: (R)-3-phenyl-2-(o-tolyloxy)propan-1-ol
• Synonyms: (R)-3-phenyl-2-(o-tolyloxy)propan-1-ol
• CAS NO: 180961-72-2
• Molecular Weight: 242.318
• Mol File: 180961-72-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-3-phenyl-2-(o-tolyloxy)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-phenyl-2-(o-tolyloxy)propan-1-ol(180961-72-2)
• EPA Substance Registry System: (R)-3-phenyl-2-(o-tolyloxy)propan-1-ol(180961-72-2)

Safety Data

• Hazardous Substances Data: 180961-72-2(Hazardous Substances Data)

Upstream product

• 444575-93-3 (R)-(-)-1-phenyl-1-(2-methylphenoxy)-2-propene 
• 2665-12-5 tris(2-methylphenyl) borate 
• 106760-61-6 (R)-(+)-2-Phenyloxetane 
• 33603-90-6 (2Z)-2-bromo-3-phenyl-2-propenal 
• 104-55-2 3-phenyl-propenal 
• 77118-87-7 (S)-1-Phenyl-3-buten-1-ol 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 66583-43-5 (+)N-methyl-ephedrine methiodide 
• 104713-12-4 (R)-1-phenylprop-2-en-1-ol 
• 321-98-2 (1S,2R)-(+)-ephedrine 

Downstream Products

• 105314-52-1 (R)-tomoxetine 

Relevant articles and documents

One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

A one-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins has been realized for the preparation of chiral 3-aryl-3-aryloxy alcohols with excellent yields and good enantioselectivities. This methodology can be employed in new synthetic routes for the synthesis of fluoxetine, atomoxetine, and related analogues.

A stereospecific ruthenium-catalyzed allylic alkylation

Good regioselectivity and chirality transfer for aryl-substituted allyl units is achieved in allylic alkylations with a wide range of nucleophiles by using the highly active ruthenium catalyst 1. This method provides a route to antidepressants such as (-)-fluoxetine from (S)-ephedrine (see scheme; Cp* = η5-C5Me5, TBAT = tetrabutylammonium triphenyldifluorosilicate).