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180968-44-9

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  • (1'S,2'S,12S,15R)-15-[2'-[[(FURANYLOXY)CARBONYL]AMINO]-1'-HYDROXY-3'-PHENYLPROP-1'-YL]-13-(1-METHYLETHYL)-10,13,16-TRIAZA-1,4,7-TRIOXA-11,14-DIOXO[17]PARACYCLOPHANECAS

    Cas No: 180968-44-9

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180968-44-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 180968-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,9,6 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 180968-44:
(8*1)+(7*8)+(6*0)+(5*9)+(4*6)+(3*8)+(2*4)+(1*4)=169
169 % 10 = 9
So 180968-44-9 is a valid CAS Registry Number.

180968-44-9Downstream Products

180968-44-9Relevant articles and documents

Paracyclophanes: A novel class of water-soluble inhibitors of HIV proteinase

Ettmayer, Peter,Billich, Andreas,Hecht, Peter,Rosenwirth, Brigitte,Gstach, Hubert

, p. 3291 - 3299 (2007/10/03)

A versatile synthesis of functionalized para- and metacyclophanes (macrocycles with one or more aromatic rings incorporated; ansa-compounds) has been developed. Cyclophanes constitute a novel building block for potent human immunodeficiency virus (HIV) protease inhibitors. The synthesis of the macrocyclic ring system was achieved by regio- and stereospecific ring opening of N-protected 4-amino-2,3-epoxy-5-phenylpentanoates with appropriate α,ω-diamines and consecutive ring closure under high dilution conditions. The resulting macrocyclic building blocks enabled further broad and flexible derivation. Paracyclophanes, containing oxyethylene substructures, were found to dissolve in phosphate-buffered saline at concentrations as high as 3 mg/mL at physiological pH. Several derivatives with K(i) values lower than 10 nM and antiviral activities in the range of 15-50 nM have been obtained. The influence of the ring size and of the substitution pattern of the cyclophane moiety on enzyme inhibition, antiviral activity, and water solubility are discussed. Preliminary data on oral bioavailability in mice are given for selected compounds.

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