18103-41-8

Usage

Type of compound

Flavonoid

Sources

Citrus fruits (tangerines, oranges)

Health benefits

+ Anti-inflammatory
+ Anti-cancer
+ Neuroprotective

Potential applications

+ Preventing and treating cancer
+ Preventing and treating cardiovascular disease
+ Preventing and treating neurodegenerative disorders
+ Improving metabolic health
+ Reducing obesity-related complications

Other effects

Antioxidant and anti-inflammatory properties

Possible uses

Pharmaceutical and nutraceutical industries.

Upstream product

• 18103-42-9 5,7-dihydroxy-3',4',5'-trimethoxyflavone 
• 77-78-1 dimethyl sulfate 
• 53350-26-8 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 108-73-6 3,5-dihydroxyphenol 
• 1719-88-6 3,4,5-trimethoxybenzoic anhydride 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 53350-27-9 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 

Downstream Products

• 89456-44-0 5,8-dihydroxy-7-methoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 80324-51-2 3′,4′,5,5′,7,8-hexahydroxyflavone hexamethyl ether 
• 68708-52-1 3',4',5',5,6,7-hexahydroxyflavone 
• 117804-02-1 5-Methoxy-2-[5-(3,4,5-trimethoxy-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol 

Relevant academic research and scientific papers

Synthesis of Benzopyran-Fused Flavone Derivatives via Microwave-Assisted Intramolecular C-H Activation

A microwave-assisted intramolecular direct arylation method for the synthesis of benzopyran-fused flavone derivatives containing natural flavone backbones is described. Different polyalkoxy flavones were synthesized and functionalized with 2-bromobenzyl bromide. The resulting compounds were subjected to palladium-catalyzed intramolecular direct arylation reactions supported by microwave irradiation to produce fused tetracyclic flavones. In the case of the 7-substituted chrysin derivative, the regioselectivity of the coupling was also examined.

Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

Synthesis of novel flavonoid derivatives as potential HIV-integrase inhibitors

Eighteen novel flavonoid derivatives - substituted chalcones and flavones were synthesized and characterized by using NMR, IR, UV/Vis spectroscopy and elemental analysis. The target compounds were achieved by using a sequence of simple and effective reactions starting from phloroglucinol. The initial hydroxyl groups were protected by methylation and in the final flavones the 5-OH group was selectively demethylated by means of AlBr3. 5-methoxy flavones exhibit a strong fluorescence, which was quenched after the removal of the methyl group.

Synthesis and Characterization of Ruthenium(II) Complexes of 5-Hydroxyflavones

Bis(dimethyl sulfoxide)bis(flavonato)ruthenium(II) complexes, RuL2(DMSO)2, were synthesized by the reaction of dichlorotetrakis(dimethyl sulfoxide)ruthenium(II) with the sodium salts of 5-hydroxyflavone, 5-hydroxy-4'-methoxyflavone, and 5-hydroxy-3',4',5'

The Preparation of Flavones and their Derivatives. Part I. Flavones and 4-Thioflavones.

A series of polysubstituted flavones has been prepared with particular emphasis on 3',4',5',5,7-pentahydroxyflavone and its ether derivatives.The preparation of 4-thioflavones has been undertaken to provide intermediates for the preparation of 4-iminoflav