18103-41-8

Basic information

• Product Name: 2-(3,4,5-Trimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
• Synonyms: 2-(3,4,5-Trimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one;5-Hydroxy-7-methoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one;Corymbosin
• CAS NO: 18103-41-8
• Molecular Formula: C₁₉H₁₈O₇
• Molecular Weight: 358.34
• Mol File: 18103-41-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 195-196 °C(Solv: ethanol (64-17-5))
• Boiling Point: 561.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.309±0.06 g/cm3(Predicted)
• PKA: 6.31±0.40(Predicted)
• CAS DataBase Reference: 2-(3,4,5-Trimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4,5-Trimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one(18103-41-8)
• EPA Substance Registry System: 2-(3,4,5-Trimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one(18103-41-8)

Safety Data

• Hazardous Substances Data: 18103-41-8(Hazardous Substances Data)

Usage

Type of compound

Flavonoid

Sources

Citrus fruits (tangerines, oranges)

Health benefits

+ Anti-inflammatory
+ Anti-cancer
+ Neuroprotective

Potential applications

+ Preventing and treating cancer
+ Preventing and treating cardiovascular disease
+ Preventing and treating neurodegenerative disorders
+ Improving metabolic health
+ Reducing obesity-related complications

Other effects

Antioxidant and anti-inflammatory properties

Possible uses

Pharmaceutical and nutraceutical industries.

Upstream product

• 1719-88-6 3,4,5-trimethoxybenzoic anhydride 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 108-73-6 3,5-dihydroxyphenol 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 53350-26-8 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 53350-27-9 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 18103-42-9 5,7-dihydroxy-3',4',5'-trimethoxyflavone 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 117804-02-1 5-Methoxy-2-[5-(3,4,5-trimethoxy-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol 
• 80324-51-2 3′,4′,5,5′,7,8-hexahydroxyflavone hexamethyl ether 
• 68708-52-1 3',4',5',5,6,7-hexahydroxyflavone 
• 89456-44-0 5,8-dihydroxy-7-methoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 

Relevant articles and documents

Synthesis of Benzopyran-Fused Flavone Derivatives via Microwave-Assisted Intramolecular C-H Activation

A microwave-assisted intramolecular direct arylation method for the synthesis of benzopyran-fused flavone derivatives containing natural flavone backbones is described. Different polyalkoxy flavones were synthesized and functionalized with 2-bromobenzyl bromide. The resulting compounds were subjected to palladium-catalyzed intramolecular direct arylation reactions supported by microwave irradiation to produce fused tetracyclic flavones. In the case of the 7-substituted chrysin derivative, the regioselectivity of the coupling was also examined.

Synthesis of novel flavonoid derivatives as potential HIV-integrase inhibitors

Eighteen novel flavonoid derivatives - substituted chalcones and flavones were synthesized and characterized by using NMR, IR, UV/Vis spectroscopy and elemental analysis. The target compounds were achieved by using a sequence of simple and effective reactions starting from phloroglucinol. The initial hydroxyl groups were protected by methylation and in the final flavones the 5-OH group was selectively demethylated by means of AlBr3. 5-methoxy flavones exhibit a strong fluorescence, which was quenched after the removal of the methyl group.

The Preparation of Flavones and their Derivatives. Part I. Flavones and 4-Thioflavones.

A series of polysubstituted flavones has been prepared with particular emphasis on 3',4',5',5,7-pentahydroxyflavone and its ether derivatives.The preparation of 4-thioflavones has been undertaken to provide intermediates for the preparation of 4-iminoflav