18119-98-7Relevant articles and documents
Some 2,3-fused diaza-heterocycles of estra-1,3,5(10)-trien-17-one.
Conrow,Bernstein
, p. 151 - 164 (1968)
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An improved synthesis of 3-aminoestrone
Sch?n, Uwe,Messinger, Josef,Buchholz, Monika,Reinecker, Uwe,Thole, Hubert,Prabhu, Manoj K. S.,Konda, Ashok
, p. 7111 - 7115 (2005)
An efficient Pd(0)-catalyzed protocol for the rapid and efficient preparation of 3-aminoestrone via 3-benzylaminoestrone from estrone-triflate is described. The three step synthesis proceeds with an overall yield of about 55% using X-Phos as optimal ligan
Metal-Free Geminal Difunctionalization of Diazocarbonyl Compounds: A One-Pot Multicomponent Strategy for the Construction of α,β-Diamino Carbonyl Derivatives
Zhu, Dan,Yao, Yuan,Zhao, Rong,Liu, Yang,Shi, Lei
, p. 4805 - 4809 (2018/03/21)
An unprecedented three-component domino oxidative coupling of diazocompounds for the efficient synthesis of α-azido-β-amino esters with non-activated dimethylamino compounds and simple TMSN3 was achieved. The main features of this method include metal-free catalysis, satisfactory functional group tolerance, general applicability in complex molecule architectures, and excellent diastereoselectivity in the presence of chiral auxiliaries. In addition, several related control experiments have been conducted to investigate the reaction mechanism.
TOPICAL ANTIANDROGENIC STEROIDS
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Page 29; 31, (2010/02/09)
Steroidal antiandrogens and pharmaceutical compositions thereof, are used for reduction of the risk of developing, or for treatment of, androgen-dependent skin related diseases. In preferred embodiments, the antiandrogen EM-3180 is used for reduction of t