18121-89-6Relevant academic research and scientific papers
Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches
Boraei, Ahmed T.A.,Eltamany, Elsayed H.,Ali, Ibrahim A.I.,Gebriel, Sara M.,Nafie, Mohamed S.
, (2021/04/27)
Liver cancer is the most common type of cancer in many countries. New studies and statistics show rising liver cancer worldwide, so it is essential to seek new agents for this type of cancer. PIM1 has an attractive target in the discovery of cancer medica
Synthesis and biological evaluation of some tacrine analogs: Study of the effect of the chloro substituent on the acetylcholinesterase inhibitory activity
Ragab, Hanan M.,Ashour, Hayam M. A.,Galal, Amal,Ghoneim, Asser I.,Haidar, Hassan R.
, p. 539 - 552 (2016/03/19)
New tetrahydroquinoline derivatives were synthesized, characterized, and evaluated for their in vitro and in vivo acetylcholinesterase inhibitory activity as well as hepatotoxicity using tacrine as a reference standard. The obtained results revealed that
One-Pot Synthesis of 3-Cyano-2-pyridones
Wang, Yingcai,Liu, Gang,Reyes, Jeremy Chris P.,Duverna, Randolph
, p. 1185 - 1191 (2015/08/06)
A versatile synthesis of 3-cyano-2-pyridones via a one-pot, four-component condensation of ethyl cyanoacetate, ketones, aldehydes, and ammonium acetate under very mild conditions has been developed. This method provides rapid access to this type of valuab
Efficient one-pot four-component synthesis and X-ray crystallographic structure of 2-pyridone derivatives
Balalaie, Saeed,Hashemi, Mohammed M.,Khezri, S. Hadi,Rominger, Frank,Ghabraie, Elmira,Oeser, Thomas
, p. 1272 - 1280 (2014/01/06)
A series of 3-cyano-2-pyridone derivatives were synthesized by one-pot four-component condensation reaction involving a benzaldehyde derivative, alkyl cyanoacetate, acyclic or cyclic ketones, and ammonium acetate in reflux condition. The X-ray structure of the products 5a and 5d confirm symmetric dimers via hydrogen bonding interactions between individual pyridine molecules showing, in addition, also π-π stacking interactions.
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones
Radi, Marco,Vallerini, Gian Paolo,Petrelli, Alessia,Vincetti, Paolo,Costantino, Gabriele
supporting information, p. 6905 - 6908 (2019/04/10)
A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been developed. The present method proved to be effective on a series of commercially available aldehydes, ketones and amines and could be profitably exploited in drug-discovery settings for the rapid identification of biologically relevant hit compounds.
An efficient synthesis of pyrazolo[3,4- b]quinolin-3-amine and benzo[b][1,8]naphthyridine derivatives
Elkholy, Yehya M.
, p. 361 - 372 (2007/10/03)
2-Oxo-4-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (10) reacted with hydrazine hydrate, phenylisothiocyanate or benzoyl chloride to give derivatives 12, 13 and 15, respectively. The latter two products were treated with hydrazine hydrate to affo
CYCLIZATION OF NITRILES. X. ENAMINO NITRILES OF THE 1,3-DITHIA-4-CYCLOHEXENE SERIES AND THEIR RECYCLIZATION TO DERIVATIVES OF PYRIDINE AND THIAZOLE
Sharanin, Yu. K.,Shestopalov, A. M.,Promonenkov, V. K.,Rodinovskaya, L. A.
, p. 1402 - 1415 (2007/10/02)
The recyclization of 4-amino-6-aryl-5-cyano-2-cyclopentane(cyclohexane)spiro-1,3-dithia-4-cyclohexenes, obtained from gem-dithiols and arylidenemalononitriles, leads to the formation of 4-aryl-5,6-polymethylene-3-cyano-2-(1H)-pyridinethiones.The latter are used in the synthesis of various 3-aminothienopyridines, 4-aryl-3-amino-5,6,7,8-tetrahydrothienoquinolines, and other heterocyclic compounds condensed with quinoline. 1-Cyano-1-(4-aryl-2-thiazolyl)-2-arylethylenes were obtained by the reaction of the 1,3-dithia-4-cyclohexenes with phenacyl bromides.
