181288-08-4Relevant articles and documents
Nickel-catalyzed Negishi cross-coupling reactions of secondary alkylzinc halides and aryl iodides
Joshi-Pangu, Amruta,Ganesh, Madhu,Biscoe, Mark R.
supporting information; experimental part, p. 1218 - 1221 (2011/04/27)
A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and β-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.(Figure Presented)
9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines
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, (2008/06/13)
A series of 9-(substituted amino)imidazo[4,5-f]quinolines are effective anthelmintic agents; particularly in respect to the tapeworm Hymenolepis nana.