Synthesis of [18F]-1-(3-fluoropropyl)-4-(4-cyanohenoxymethyl)- piperidine: A potential sigma-1 receptor radioligand for PET

DOI: 10.1002/(SICI)1099-1344(199609)38:9<785::AID-JLCR901>3.0.CO;2-B

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 785 - 794 (1996)

Update date:2022-07-30

Topics:

Authors:

Collier, T. Lee

O'Brien, Joanne C.

Waterhouse, Rikki N.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199609)38:9<785::AID-JLCR901>3.0.CO;2-B

[¹⁸F]-1-(3-Fluoropropyl)-4-(4-cyanophenoxymethyl) piperidine has been prepared as a potential sigma-1 receptor ligand for PET. The unlabeled ligand was found to be selective in vitro for the sigma-1 receptor [Ki(σ₁) = 4.3 nM] when te

Full text of DOI:10.1002/(SICI)1099-1344(199609)38:9<785::AID-JLCR901>3.0.CO;2-B

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