181526-18-1

Usage

Uses

Used in Organic Synthesis:
Furo[3,2-b]pyridine,4-oxide(9CI) is utilized as a key intermediate in the synthesis of complex organic molecules, particularly in the preparation of pharmaceuticals, agrochemicals, and other functional materials. Its unique structure allows for versatile chemical modifications, facilitating the creation of a wide range of compounds with diverse applications.
Used in Pharmaceutical Development:
In the pharmaceutical industry, Furo[3,2-b]pyridine,4-oxide(9CI) serves as a building block for the development of new drugs. Its unique properties enable the design of molecules with specific biological activities, contributing to the discovery of novel therapeutic agents.
Used as a Catalyst in Organic Transformations:
Furo[3,2-b]pyridine,4-oxide(9CI) has demonstrated potential as an effective catalyst in various organic reactions. Its ability to facilitate chemical transformations under mild conditions makes it a valuable tool in the synthesis of complex organic compounds, enhancing the efficiency and selectivity of these processes.
Used as a Fluorescent Probe for Molecular Imaging:
Furo[3,2-b]pyridine,4-oxide(9CI) has shown promise as a fluorescent probe for molecular imaging applications. Its optical properties allow for the visualization and tracking of specific molecular targets, providing valuable insights into biological processes and facilitating the development of targeted therapies.

InChI:InChI=1/C7H5NO2/c9-8-4-1-2-7-6(8)3-5-10-7/h1-5H

Upstream product

• 272-62-8 furo[3,2-b]pyridine 
• 92671-70-0 acetic acid 2-bromopyridin-3-yl ester 
• 6602-32-0 2-bromo-pyridin-3-ol 

Downstream Products

• 182691-67-4 5-cyanofuro<3,2-b>pyridine 
• 853680-58-7 (2R)-[1-(4-chlorobenzyl)-2-(4-furo[3,2-b]pyridin-7-yl-piperazin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 182691-75-4 7-chlorofuro[3,2-b]pyridine 
• 56473-91-7 furo<3,2-b>pyridine-5-carboxylic acid 
• 190957-95-0 Furo[3,2-b]pyridine-7-carbonitrile 
• 182691-76-5 5-chlorofuro[3,2-b]pyridine 

Relevant academic research and scientific papers

Furopyridines. XVII [1]. Cyanation, chlorination and nitration of furo[3,2-b]pyridine N-oxide

The N-oxide 2 of furo[3,2-b]pyridine (1) was cyanated by the Reissert-Henze reaction with potassium cyanide and benzoyl chloride to give 5-cyano derivative 3, which was converted to the carboxamide 4, carboxylic acid 5, ethyl ester 6 and ethyl imidate 8. Chlorination of 2 with phosphorus oxychloride yielded 2-9a, 3- 9b, 5- 9c and 7-chloro derivative 9d. Reaction of 9d with sodium methoxide, pyrrolidine, N,N-dimethylformamide and ethyl cyanoacetate afforded 7-methoxy- 10, 7-(1-pyrrolidyl)- 11 and 7-dimethylaminofuro[3,2-b]pyridine (14) and 7-(1-cyano-1-ethoxy-carbonyl)methylene-4,7-dihydro-furo[3,2-b]pyridine (12). Nitration of 2 with a mixture of fuming nitric acid and sulfuric acid gave 2-nitrofuro[3,2-b]pyridine N-oxide (15).

GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.