182691-75-4

Usage

Uses

Used in Pharmaceutical Research:
7-Chloro-furo[3,2-b]pyridine is used as a building block in organic synthesis for the development of new drugs. Its unique structure and functional groups make it a valuable intermediate in the synthesis of biologically active compounds, contributing to the discovery of novel therapeutic agents.
Used in Agrochemical Development:
7-Chloro-furo[3,2-b]pyridine may have potential applications in the development of agrochemicals. Its chemical properties and reactivity can be harnessed to create new compounds with pesticidal, herbicidal, or other agricultural uses, enhancing crop protection and yield.
Used in Materials Science:
In the field of materials science, 7-Chloro-furo[3,2-b]pyridine can be utilized to develop new materials with specific properties. Its heterocyclic structure and functional groups can be incorporated into the design of advanced materials for various applications, such as sensors, catalysts, or functional polymers.
Overall, 7-Chloro-furo[3,2-b]pyridine is a versatile chemical compound with a wide range of potential applications across different industries, including pharmaceuticals, agrochemicals, and materials science. Its unique structure and reactivity make it an attractive candidate for further research and development.

Upstream product

• 181526-18-1 4-oxidofuro[3,2-b]pyridin-4-ium 
• 111079-44-8 2-trimethylsilylfuro<3,2-b>pyridine 
• 1071540-49-2 2-(trimethylsilanyl)furo[3,2-b]pyridine 4-oxide 
• 1071540-51-6 7-chloro-2-(trimethylsilanyl)furo[3,2-b]pyridine 
• 13061-96-6 dihydroxy-methyl-borane 
• 1071540-54-9 7-chloro-2-iodofuro[3,2-b]pyridine 
• 92671-70-0 acetic acid 2-bromopyridin-3-yl ester 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 272-62-8 furo[3,2-b]pyridine 

Downstream Products

• 1533781-17-7 7-hydroxyfuro[3,2-b]pyridine 
• 853680-58-7 (2R)-[1-(4-chlorobenzyl)-2-(4-furo[3,2-b]pyridin-7-yl-piperazin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

NOVEL JAK1 SELECTIVE INHIBITORS AND USES THEREOF

The new 1H-furo[3,2-b]imidazo[4,5-d]pyridine derivatives are selective Jak1 kinase inhibitors useful in treating disorders related to Jak1 activities such as autoimmune diseases or disorders, inflammatory diseases or disorders, and cancer or neoplastic di

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Furopyridines. XVII [1]. Cyanation, chlorination and nitration of furo[3,2-b]pyridine N-oxide

The N-oxide 2 of furo[3,2-b]pyridine (1) was cyanated by the Reissert-Henze reaction with potassium cyanide and benzoyl chloride to give 5-cyano derivative 3, which was converted to the carboxamide 4, carboxylic acid 5, ethyl ester 6 and ethyl imidate 8. Chlorination of 2 with phosphorus oxychloride yielded 2-9a, 3- 9b, 5- 9c and 7-chloro derivative 9d. Reaction of 9d with sodium methoxide, pyrrolidine, N,N-dimethylformamide and ethyl cyanoacetate afforded 7-methoxy- 10, 7-(1-pyrrolidyl)- 11 and 7-dimethylaminofuro[3,2-b]pyridine (14) and 7-(1-cyano-1-ethoxy-carbonyl)methylene-4,7-dihydro-furo[3,2-b]pyridine (12). Nitration of 2 with a mixture of fuming nitric acid and sulfuric acid gave 2-nitrofuro[3,2-b]pyridine N-oxide (15).