1816-91-7Relevant articles and documents
A study of the thermal decomposition of 2-azidoacetamide by ultraviolet photoelectron spectroscopy and matrix-isolation infrared spectroscopy: Identification of the imine intermediate H2NCOCHNH
Dyke,Levita,Morris,Ogden,Dias,Algarra,Santos,Costa,Rodrigues,Barros
, p. 5299 - 5307 (2004)
The thermal decomposition of 2-azidoacetamide (N3CH 2CONH2) has been studied by matrix-isolation infrared spectroscopy and real-time ultraviolet photoelectron spectroscopy. N 2, CH2NH, HNCO, CO, NH3, and HCN are observed as high-temperature decomposition products, while at lower temperatures, the novel imine intermediate H2NCOCH=NH is observed in the matrix-isolation IR experiments. The identity of this intermediate is confirmed both by ab initio molecular orbital calculations of its IR spectrum and by the temperature dependence and distribution of products in the photoelectron spectroscopy (PES) and IR studies. Mechanisms are proposed for the formation and decomposition of the intermediate consistent both with the observed results and with estimated activation energies based on pathway calculations.
Synthesis of (1H-1,2,3-Triazol-1-yl)acetic Acid Derivatives
Obushak, M. D.,Pokhodylo, N. T.,Savka, R. D.
, p. 1421 - 1431 (2020/10/02)
Abstract: A convenient synthetic approach to (1H-1,2,3-triazol-1-yl)acetic acid derivatives via the reaction of azidoacetamides with β-ketoesters and acetylacetone is proposed. Based on this strategy, 1,5-disubstituted 1,2,3-triazoles were prepared from available reagents under metal-free conditions. A one-pot protocol for the synthesis of (5-methyl-1H-1,2,3-triazol-1-yl)acetamides derived from N-substituted chloroacetamides is developed.
Substituted diaryl nicotinamide type derivative, and preparation method and application thereof
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Paragraph 0120; 0121, (2017/08/29)
The invention relates to a substituted diaryl nicotinamide type derivative, and a preparation method and application thereof, in particular to a substituted diaryl nicotinamide type derivative shown as the general formula I and pharmaceutically-acceptable salt thereof. The invention further provides a preparation method of the compound of the general formula I, and application of a composition, comprising one or more compounds, in preparation of drugs for treating and preventing human immunodeficiency virus (HIV) infection.