181697-19-8

Basic information

• Product Name: 3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE
• Synonyms: 3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE
• CAS NO: 181697-19-8
• Molecular Formula: C₁₆H₁₂BrNO
• Molecular Weight: 314.18
• Mol File: 181697-19-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE(181697-19-8)
• EPA Substance Registry System: 3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE(181697-19-8)

Safety Data

• Hazardous Substances Data: 181697-19-8(Hazardous Substances Data)

Usage

Chemical structure

Isoxazole derivative with a bromo-phenyl group and a methyl-phenyl group attached to the isoxazole ring

Applications

Medicinal chemistry, drug discovery, building block in organic compound synthesis

Potential uses

Pharmacological properties, varied applications in chemistry and pharmaceuticals

Upstream product

• 2466-76-4 N-Acetylimidazole 
• 181697-18-7 1-(4-bromophenyl)-2-phenyl-ethan-1-one oxime 
• 1122-91-4 4-bromo-benzaldehyde 
• 100-39-0 benzyl bromide 
• 2001-29-8 1-(4-bromophenyl)-2-phenyl-ethan-1-one 

Downstream Products

• 181696-12-8 4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide 
• 181696-14-0 4-[3-(4-bromophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide 

Relevant articles and documents

Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same

The present invention relates to an isothiazole derivative of the following formula 1 or nontoxic salt thereof: wherein, R1 is hydrogen, alkoxy group or halogen group; R2 is methyl or amino group. According to the present invention, isothiazole derivative or nontoxic salt thereof having antipyretic, analgesic and antiphlogistic activity and an improved side effect; process for the preparation thereof; and pharmaceutical composition including the same can be provided.

Substituted isoxazoles for the treatment of inflammation

A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula (III) wherein R7 is selected from hydroxyl, lower alkyl, carboxyl, halo, lower carboxylalkyl, lower alkoxycarbonylalkyl, lower alkoxyalkyl, lower carboxyalkoxyalkyl, lower haloalkyl, lower haloalkylsulfonyloxy, lower hydroxyalkyl, lower aryl (hydroxylalkyl), lower carboxyaryloxyalkyl, lower alkoxycarbonylaryloxyalkyl, lower cycloalkyl, lower cycloalkylalkyl, and lower aralkyl; and wherein R8 is one or more radicals independently selected from hydrido, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; or a pharmaceutically-acceptable salt thereof.