181696-12-8Relevant articles and documents
Bisaryl substituted isoxazole compound as well as preparation method and application thereof
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, (2021/10/02)
The invention discloses a diaryl substituted isoxazole compound as well as a preparation method and a purpose thereof, particularly reports a parecoxib sodium impurity P, namely N-{4-[(5-methyl-4-phenylisoxazole-3-yl)phenyl]sulfonyl}propionamide, as well
Preparation method for impurity of parecoxib sodium
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, (2019/10/02)
The invention belongs to the technical field of medicinal chemistry, and in particular relates to a preparation method for an impurity of parecoxib sodium. A synthetic method of the compound PRN073-11is never mentioned in the prior art, a very small amoun
LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER
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Page/Page column 142, (2010/02/11)
The present invention provides a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein R1 and R3 are each sulfonamide, carbamoyl, acyl, amino, and the like, m and n are each 0 to 2, R2 and R4 are each cyano, nitro, hydroxyl, an alkoxy, a halogen, or an alkyl, Ring A is benzene or a heterocyclic ring, Ring B is benzene, a heterocyclic ring, a cycloalkane etc, and Ring Q is pyrazole or isoxazole, or a pharmaceutically acceptable salt thereof as an active ingredient.