181705-93-1

Basic information

• Product Name: 4-FLUOROPHENYLZINC BROMIDE
• Synonyms: 4-FLUOROPHENYLZINC BROMIDE;4-FLUOROPHENYLZINC BROMIDE, 0.5M SOLUTIO N IN TETRAHYDROFURAN;4-fluorophenylzinc bromide solution;4-Fluorophenylzinc bromide solution 0.5 in THF;4-Fluorophenylzinc broMide, 0.5M in THF, packaged under Argon in resealable CheMSeal^t bottles;(4-fluorophenyl)zinc(II) broMide;4-Fluorophenylzinc broMide, 0.5 M solution in THF, SpcSeal;Bromo(4-fluorophenyl)zinc
• CAS NO: 181705-93-1
• Molecular Formula: C₆H₄BrFZn
• Molecular Weight: 240.39
• Product Categories: Aryl;Organozinc Halides;Reike and Organozinc Reagents
• Mol File: 181705-93-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 84.7°C at 760 mmHg
• Flash Point: 1 °F
• Appearance: /
• Density: 0.992 g/mL at 25 °C
• Vapor Pressure: 79.9mmHg at 25°C
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-FLUOROPHENYLZINC BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHENYLZINC BROMIDE(181705-93-1)
• EPA Substance Registry System: 4-FLUOROPHENYLZINC BROMIDE(181705-93-1)

Safety Data

• Hazard Codes: F,Xn
• Statements: 19-22-36/38-40-36/37-14-11
• Safety Statements: 16-26-33-36-36/37
• RIDADR: UN 3399 4.3/PG 2
• HazardClass: 4.3
• Hazardous Substances Data: 181705-93-1(Hazardous Substances Data)

Usage

Description

4-Fluorophenylzinc bromide, also known as 4-fluorophenylzinc(II) bromide, is an organozinc compound with the chemical formula C6H5BrFZn. It is a colorless to yellow liquid with a molecular weight of 216.17 g/mol. 4-FLUOROPHENYLZINC BROMIDE is characterized by its reactivity with air and moisture, necessitating handling and storage under an inert atmosphere.

Uses

Used in Organic Synthesis:
4-Fluorophenylzinc bromide is used as a reagent in organic synthesis for forming carbon-carbon bonds through cross-coupling reactions. Its application is particularly valuable in processes such as the Suzuki-Miyaura coupling and Negishi coupling, which are widely utilized in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-fluorophenylzinc bromide serves as a valuable intermediate. Its role in the synthesis of various pharmaceutical compounds makes it instrumental in the development of new drugs and medicinal agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 4-fluorophenylzinc bromide is utilized as an intermediate in the synthesis of various agrochemicals, contributing to the development of pesticides, herbicides, and other agricultural chemicals.
Used in Chemical Research and Development:
4-Fluorophenylzinc bromide is also used in the synthesis of various materials in chemical research and development. Its versatility in forming carbon-carbon bonds makes it a key component in the advancement of new materials and chemical processes.

InChI:InChI=1/C6H4F.BrH.Zn/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q-1;;+2/p-1/rC6H4F.BrZn/c7-6-4-2-1-3-5-6;1-2/h2-5H;/q-1;+1

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
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• 7699-45-8 zinc dibromide 
• 7440-66-6 zinc 
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• 7646-85-7 zinc(II) chloride 

Downstream Products

• 697739-36-9 5-chloro-3-(4-fluorophenyl)pyridazine 
• 343319-07-3 6-(4-fluorophenyl)-6-oxohexanoic acid 

Relevant articles and documents

Control of the dual emission from a thermally activated delayed fluorescence emitter containing phenothiazine units in organic light-emitting diodes

The development of single-component organic dual light-emitting molecules is of interest for a range of applications including white organic light-emitting diodes. Herein, a new thermally-activated delayed fluorescent molecule containing 4,6-bis-phenyl ph

Synthesis of Symmetrical Diaryl Ketones by Cobalt-Catalyzed Reaction of Arylzinc Reagents with Ethyl Chloroformate

Symmetrical diaryl ketones were prepared by a cross-coupling reaction between aryl bromides and ethyl chloroformate. This new method, which uses a catalyst composed of CoBr2and a bipyridine ligand along with readily available starting materials, allows for the synthesis of a variety of symmetrical diaryl ketones in moderate to excellent yields (37–99 %) under mild conditions. This reaction, in which ethyl chloroformate acts as a surrogate of carbon monoxide in the presence of cobalt and zinc, represents an interesting alternative to previously known approaches for the synthesis of diarylmethanones.

CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides

In this study, a facile CuI catalyzed synthesis of sulfones involving a nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides is realized. This reaction proceeds efficiently at room temperature, giving rise to various functional group substituted sulfones, generally in moderate to high yields. The method provides a novel, simple, and promising strategy for functionalized sulfone synthesis in the research field of sulfur chemistry. the Partner Organisations 2014.