18192-28-4Relevant academic research and scientific papers
Tetrahedral Silicon-Centered Dibenzoylmethanatoboron Difluorides: Synthesis, Crystal Structure, and Photophysical Behavior in Solution and the Solid State
Kononevich, Yuriy N.,Temnikov, Maxim N.,Korlyukov, Alexander A.,Volodin, Alexander D.,Dorovatovskii, Pavel V.,Sazhnikov, Viacheslav A.,Safonov, Andrey A.,Ionov, Dmitriy S.,Ivanov, Anatoly A.,Surin, Nikolay M.,Svidchenko, Evgeniya A.,Muzafarov, Aziz M.
, p. 1111 - 1119 (2020/04/07)
Four tetrahedral silicon-centered derivatives of dibenzoylmethanatoboron difluoride (DBMBF2) were synthesized and characterized. Their structural and optical features both in solution and the solid state were investigated by using X-ray crystal
Application of a promiscuous Arthrobacter sp. from Antarctic in aerobic (R)-selective deracemization and anaerobic (S)-selective reduction
Palmeira, Dayvson J.,Arajo, Lidiane S.,Abreu, Juliana C.,Andrade, Leandro H.
, p. 117 - 125 (2015/02/19)
Inspired by enzyme-catalyzed reactions with microorganisms found in harsh marine environments, in which the amount of oxygen is restrict, we have shown that Arthrobacter sp. can perform different chemical transformations by switching from anaerobic to aerobic reaction conditions. Depending on the presence or absence of oxygen, either alcohol deracemization or ketone reduction with enantiocomplementary selectivities can be performed by the same microorganism. For example, reactions performed in the presence of oxygen favored the deracemization process, in which a racemic mixture of 1-(4-methylphenyl)ethanol was enriched to the (R)-alcohol in high conversion (94%) and high enantiomeric excess (94%). On the other hand, reaction in the absence of oxygen favored the reduction process, in which 4-methyl-acetophenone was converted to the (S)-alcohol in good conversion (58%) and excellent enantiomeric excess (>99%). These concepts were applied for both deracemization and enantioselective reduction of heteroatom-containing (silicon, phosphorus, tin and boron) molecules. Moreover, preparative scale reactions were also performed for both chemical processes.
Enantioselective syntheses of 2-arylpropanoic acid non-steroidal antiinflammatory drugs and related compounds
Hamon, David P.G.,Massy-Westropp, Ralph A.,Newton, Josephine L.
, p. 12645 - 12660 (2007/10/02)
(S)-2-[4′-(2″-Methylpropyl)phenylpropanoic acid (ibuprofen) and (S)-2-(3′-benzoylphenyl)propanoic acid (ketoprofen) have been synthesised in high enantiomeric excess. Control of stereochemistry was achieved by a combination of Sharpless epoxidalion followed by catalytic hydrogenolysis of the introduced benzylic epoxide oxygen bond. Also, the coupling of organic compounds in the presence of palladium with enantiopure 2-(3-iodophenyl)propanoic and 2-(4-iodophenyl)propanoic acids, prepared by the methodology above, is a general method for the synthesis of optically active arylpropanoic acids.
Retinobenzoic Acids. 5. Retinoidal Activities of Compounds Having a Trimethylsilyl or Trimethylgermyl Group(s) in Human Promyelocytic Leukemia Cells HL-60
Yamakawa, Takeru,Kagechika, Hiroyuki,Kawachi, Emiko,Hashimoto, Yuichi,Shudo, Koichi
, p. 1430 - 1437 (2007/10/02)
The retinoidal activities of trimethylsilyl or trimethylgermyl-containing retinobenzoic acids are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60.Compounds with a trimethylsilyl or trimethylgermyl gr
Etude spectroscopique des p-trimethylsilyl, p-trimethylgermyl et p-trimethylstannylacetophenones
Maire, Jean-Claude,Marrot, Jean,Nabet, Roger
, p. 429 - 434 (2007/10/02)
Acylation of phenyltrimethylstannane in Friedel and Crafts reaction leads exclusively to cleavage of the tin-carbon bond.However, p-trimethylsilylacetophenone and its germanium and tin analogs have been sinthesized by reaction of the Grignard derivative o
