182007-76-7

Upstream product

• 622-33-3 N-benzyloxyamine 
• 6973-20-2 (S)-methylsuccinic anhydride 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 2174-58-5 L-malic acid 

Downstream Products

• 182007-77-8 (3S)-Boc-L-valine-(4S)-methyl-N-O-benzylsuccinimide 
• 618109-44-7 C₂₄H₃₂N₂O₆ 
• 532393-80-9 (3S)-N-Boc-3-amino-β-phenylalanine-L-valine-(4S)-methylsuccinimide 
• 792903-64-1 (3S)-β-phenylalanine-L-valine-(4S)-methylsuccinimide 

Relevant academic research and scientific papers

Asymmetric synthesis of moiramide B

The first asymmetric synthesis of Moiramide B 1 is achieved using lithium amide 4 and pyrrolidinone auxiliary 5; pyrrolidinone auxiliary 5 is used to create the novel (S)-2-methyl-N-benzyloxysuccinimide 15 which is subsequently acylated with the highly re

Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase

There is an urgent demand for the development of new antibiotics due to the increase in drug-resistant pathogenic bacteria. A novel target is the multifunctional enzyme acetyl-CoA carboxylase (ACC), which catalyzes the first committed step in fatty acid s

Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action

The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure-activity relationship (SAR) studies revealed a high degree of variability for the fa

SUBSTITUTED ALKYLAMIDES

The invention relates to compounds, method for producing them, pharmaceutical compositions comprising them and the use thereof in the treatment and/or prophylaxis of human or animal diseases, especially bacterial infectious diseases.

Asymmetric syntheses of moiramide B and andrimid

The first highly diastereoselective asymmetric syntheses of moiramide B 2 and andrimid 3 have been achieved using lithium amide (R)-6 and pyrrolidinone auxiliary (R)-9. Pyrrolidinone auxiliary (R)-9 was used to create the novel (S)-3-methyl-N-benzyloxysuc