792903-64-1Relevant academic research and scientific papers
Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase
Silvers, Molly A.,Robertson, Gregory T.,Taylor, Carol M.,Waldrop, Grover L.
, p. 8947 - 8959 (2015/03/14)
There is an urgent demand for the development of new antibiotics due to the increase in drug-resistant pathogenic bacteria. A novel target is the multifunctional enzyme acetyl-CoA carboxylase (ACC), which catalyzes the first committed step in fatty acid s
Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action
Pohlmann, Jens,Lampe, Thomas,Shimada, Mitsuyuki,Nell, Peter G.,Pernerstorfer, Josef,Svenstrup, Niels,Brunner, Nina A.,Schiffer, Guido,Freiberg, Christoph
, p. 1189 - 1192 (2007/10/03)
The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure-activity relationship (SAR) studies revealed a high degree of variability for the fa
