18213-38-2

Upstream product

• 137444-51-0 (2E)-3-(4-methoxyphenyl)-1-thiophen-2-yl-prop-2-en-1-one 
• 100-63-0 phenylhydrazine 
• 123-11-5 4-methoxy-benzaldehyde 
• 59-88-1 phenylhydrazine hydrochloride 
• 6028-93-9 (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 1237750-01-4 C₂₀H₁₆N₂OS 

Relevant academic research and scientific papers

Synthesis of 3,5-disubstituted pyrazoles and their derivatives

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-one (Ia-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e) and also treated with DMSO in presence of catalytic amount of iodine to give pyrazole (II′a-e) Similarly, 1-phenyl pyrazoline (IIIa-e) treated with DMSO/I2 to give 1-phenyl pyrazole(III′a- e), 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) treated with DMSO/I2 to give 1-(2,4-dinitro phenyl) pyrazole(IV′a-e), 1-carboxamido pyrazoline (Va-e) treated with DMSO/I2 to give 1-carboxamido pyrazole (V′a-e), 1-acetyl pyrazoline (VIa-e) treated with DMSO/I2 to give 1-acetyl pyrazole (VI′a-e), 1-benzoyl pyrazoline (VIIa-e) treated with DMSO/I2 to give 1-benzoyl pyrazole (VII′a-e) and 1-nitroso pyrazoline (VIIIa-e) treated with DMSO/I2 to give 1-nitroso pyrazole (VIII′a-e). Characterization and structural elucidation was carried out on the basis of melting points determination, analytical and spectral studies.

Heterocycles. 3. Synthesis and Spectral Data of Some 2-Pyrazolines

The reaction of 1,3-diaryl-2-propen-1-ones (Ia-o) with hydrazine and methyl- and phenylhydrazine produced different substituted 2-pyrazolines (III).The structures of these products were evident from their chemical and spectroscopic analysis.