5-(4-methoxyphenyl)-1-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 5-(4-methoxyphenyl)-1-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
• CAS No.: 18213-38-2
• Molecular Formula: C₂₀H₁₈N₂OS
• Molecular Weight: 334.442
• Mol file: 18213-38-2.mol

Synonyms:5-(4-methoxy-phenyl)-1-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole

Chemical Property of 5-(4-methoxyphenyl)-1-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-(4-methoxyphenyl)-1-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole

There total 6 articles about 5-(4-methoxyphenyl)-1-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2E)-3-(4-methoxyphenyl)-1-thiophen-2-yl-prop-2-en-1-one (137444-51-0) + phenylhydrazine (100-63-0) → 5-(4-methoxy-phenyl)-1-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole (18213-38-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/je00036a038

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → 5-(4-methoxy-phenyl)-1-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole (18213-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 2 h

2: 91 percent / KOH / ethanol / 3 h / Heating

With potassium hydroxide; sodium hydroxide; In ethanol;

DOI:10.1021/je00036a038

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 5-(4-methoxy-phenyl)-1-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole (18213-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 2 h

2: 91 percent / KOH / ethanol / 3 h / Heating

With potassium hydroxide; sodium hydroxide; In ethanol;

DOI:10.1021/je00036a038

upstream raw materials:

(2E)-3-(4-methoxyphenyl)-1-thiophen-2-yl-prop-2-en-1-one

phenylhydrazine

2-Acetylthiophene

4-methoxy-benzaldehyde

Downstream raw materials:

C₂₀H₁₆N₂OS