182165-50-0Relevant academic research and scientific papers
Highly regioselective indoline synthesis under nickel/photoredox dual catalysis
Tasker, Sarah Z.,Jamison, Timothy F.
, p. 9531 - 9534 (2015)
Nickel/photoredox catalysis is used to synthesize indolines in one step from iodoacetanilides and alkenes. Very high regioselectivity for 3-substituted indoline products is obtained for both aliphatic and styrenyl olefins. Mechanistic investigations indic
Intermolecular dearomative C2-arylation of N-Ac indoles activated by FeCl3
Nandi, Raj Kumar,Ratsch, Friederike,Beaud, Rodolphe,Guillot, Régis,Kouklovsky, Cyrille,Vincent, Guillaume
, p. 5328 - 5331 (2016/04/26)
We report the FeCl3-mediated direct addition of electron-rich arenes to the C2-position of electrophilic N-Ac indoles under mild conditions (room temperature, air). No functional group is required on the arene nucleophile: one of its C-H bonds is added to the C2=C3 double bond of the indole nucleus in a Friedel-Crafts-type reaction. This dearomatisation process delivered a broad range of C2-arylated indolines.
Process for producing indoline compounds and intermediates for the production of the same
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, (2008/06/13)
This invention concerns a method for the production of a 3-arylindoline compound represented by the general formula STR1
