182267-22-7

Basic information

• Product Name: 4-Oxazolidinecarboxylicacid,5-methyl-2-oxo-,methylester,(4S,5S)-(9CI)
• Synonyms: 4-Oxazolidinecarboxylicacid,5-methyl-2-oxo-,methylester,(4S,5S)-(9CI)
• CAS NO: 182267-22-7
• Molecular Formula: C6H9NO4
• Molecular Weight: 0
• Product Categories: CARBOXYLICESTER
• Mol File: 182267-22-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Oxazolidinecarboxylicacid,5-methyl-2-oxo-,methylester,(4S,5S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolidinecarboxylicacid,5-methyl-2-oxo-,methylester,(4S,5S)-(9CI)(182267-22-7)
• EPA Substance Registry System: 4-Oxazolidinecarboxylicacid,5-methyl-2-oxo-,methylester,(4S,5S)-(9CI)(182267-22-7)

Safety Data

• Hazardous Substances Data: 182267-22-7(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 60538-15-0 (2R,3S)-2-amino-3-hydroxy-butyric acid methyl ester hydrochloride 
• 109-99-9 tetrahydrofuran 
• 60538-18-3 (2R,3R)-methyl 2-amino-3-hydroxybutanoate hydrochloride 
• 67-56-1 methanol 
• 28130-04-3 Z-Thr-OEt 
• 163254-35-1 methyl 3-((tert-butoxycarbonyl)amino)butanoate 
• 80465-30-1 N-carboxy 2-amino-2-butenoic acid anhydride 
• 83791-33-7 4-(1-Bromo-ethyl)-4-methoxy-oxazolidine-2,5-dione 
• 3373-59-9 allo-Thr-OMe 
• 83791-38-2 5-methyl-2-oxo-2,3-dihydro-1,3-oxazole-4-carboxylic acid methyl ester 
• 72-19-5 L-threonine 

Downstream Products

• 60538-19-4 N-(tert-butoxycarbonyl)-l-threonine methyl ester 

Relevant articles and documents

INHIBITOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.

Visible-Light-Mediated Liberation and In Situ Conversion of Fluorophosgene

The first example for the photocatalytic generation of a highly electrophilic intermediate that is not based on radical reactivity is reported. The single-electron reduction of bench-stable and commercially available 4-(trifluoromethoxy)benzonitrile by an organic photosensitizer leads to its fragmentation into fluorophosgene and benzonitrile. The in situ generated fluorophosgene was used for the preparation of carbonates, carbamates, and urea derivatives in moderate to excellent yields via an intramolecular cyclization reaction. Transient spectroscopic investigations suggest the formation of a catalyst charge-transfer complex-dimer as the catalytic active species. Fluorophosgene as a highly reactive intermediate, was indirectly detected via its next downstream carbonyl fluoride intermediate by NMR. Furthermore, detailed NMR analyses provided a comprehensive reaction mechanism including a water dependent off-cycle equilibrium.

DIFLUOROMETHYL-AMINOPYRIDINES AND DIFLUOROMETHYL-AMINOPYRIMIDINES

The invention relates to novel phosphoinositide 3-kinase (PI3K),mammalian target of rapamycin (mTOR)and PI3K-related kinase(PIKKs)inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that