182279-48-7

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 219951-10-7 3,3,3-trifluoro-1,2-diphenyl-1-phenylsulfonylpropene 
• 591-50-4 iodobenzene 
• 14774-78-8 4-chlorophenyl lithium 
• 219951-09-4 β-CF3-α,β-diphenylvinyl sulfide 
• 137504-63-3 2,2,3,3,3-pentafluoro-1,1-bis(phenylthio)propylbenzene 
• 591-51-5 phenyllithium 

Relevant academic research and scientific papers

A highly stereoselective preparation of CF3-substituted 1-aryl-1,2-diphenylethenes: Application to the synthesis of panomifene

β-CF3-α,β-diphenylvinyl sulfide 3a was prepared stereoselectively in 77% yield from the reaction of 2 with phenyllithium at room temperature for 5 h. Oxidation of 3a with MCPBA afforded the corresponding vinyl sulfone 4a, in which (E)-4a can be

A facile stereocontrolled approach to CF3-substituted triarylethenes: Synthesis of panomifene

The stereoselective preparation and Pd-catalyzed cross-coupling reaction of boronates 2 provides a new general and convenient route to CF 3-substituted triaryl ethenes 3, in which the CF3 and Ar3 groups are cis to each other. The synthetic potential was demonstrated by the total synthesis of panomifene (Ar1 = Ar 3 = Ph, Ar2 = 4-(OHCH2CH2NHCH 2CH2O)-C6H4). Bpin = (pinacolato)boryl.

Preparation of α- or β-trifluoromethylated vinylstannanes and their cross-coupling reactions

α - or β-Trifluoromethylated vinylstannanes 1, 2a, 3 and 4 were prepared form 1,1-bis(phenylthio)-2,2,3,3,3-pentafluoropropylbenzene (5) via several steps. The cross-coupling arylation reactions of 1-4 with aryl iodides bearing a bromo, methoxy, methyl, n