153413-66-2

Upstream product

• 100-02-7 4-nitro-phenol 
• 824-78-2 4-nitrophenol sodium salt 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 162611-31-6 4-nitrophenyl-N,N-diisopropylchlorophosphoramidite 
• 153413-65-1 O,O'-bis-(4-nitrophenyl) N,N-diisopropylphosphoramidite 

Downstream Products

• 153454-33-2 O-[5'-O-(4,4-dimethoxytrityl)thymidin-3-yl]-O-[3'-O-(4,4-dimethoxytrityl)thymidin-5'-yl]N,N-diisopropylphosphoramidite 
• 153413-67-3 C₆₈H₆₆N₅O₁₇P 
• 162611-40-7 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite 
• 153413-68-4 C₆₉H₆₇Cl₂N₄O₁₄PS 
• 153413-69-5 S-(2,4-dichlorobenzyl)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(4,4'-dimethoxytrityl)thymidin-5-yl phosphoroselenothioate 
• 153454-34-3 C₆₉H₆₇Cl₂N₄O₁₄PS₂ 
• 57538-75-7 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate 
• 171081-14-4 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridate 
• 171081-18-8 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate 
• 171081-10-0 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridite 
• 182370-37-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen thiophosphorofluoridate 

Relevant academic research and scientific papers

Studies on the role of DBU in the reaction of P(III)-OAryl system with nucleoside

The involvement of a (=P-N≡)+ cationic species has been unambiguously demonstrated in the phosphitylation of nucleosides in the presence of DBU (1,8-diazabicyclo-[5.4.0]undec-7-ene) by 31P NMR spectroscopy and its reaction with benzo

Synthesis of phosphorofluoridates and phosphorofluoridothioates via the phosphoramidite approach

We present a very efficient synthetic procedure leading to the phosphorofluoridates RO-P(O)(OH)F 1 or phosphorofluoridothioates RO-P(S)(OH)F 2, which is based on the intermediary of fluorophosphoramidites (RO)P(F)N iPr2 5 [R = 9-(hyd

New efficient synthesis of thymidine cyclic 3′, 5′-phosphorofluoridate and its sulfur analogue via the phosphoroamidite route

We describe the convenient synthesis of thymidine cyclic 3′, 5′-phosphorofluoridate 6, which is superior to that previously reported. Our procedure is based on a sequence of reactions utilizing 3 as the key substrate. Similar sequence of reaction leads to

Synthesis of 2'-Deoxynucleosid-3'-yl-N,N-Diisopropylaminophosphorfluoridites. A New Class of Stable PIII Nucleotides Containing a P-F Bond

A new methodology based on phosphitylating reagents containing 4-nitrophenoxy leaving group has been employed to synthesize stable 5'-O-(4,4'-dimethoxytrityl)nucleosid-3'-yl-N,N-diisopropylaminophosphofluoridites 1a-d.

New phosphitylating reagent in the nucleotide chemistry containing two 4-nitrophenoxy leaving groups. Remarkably fast and clean phosphitylations activated by DBU leading to thio- and seleno-oligonucleotides

A new synthetic approach to modified oligonucleotides based on N,N′-diisopropyl-di-(4-nitrophenyl)phosphoroamidite 1 is described. The procedure involves displacement of either 4-nitrophenoxy or diisopropylamino ligands. The former proceeds very fast in t