1825-66-7

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 14898-79-4 (2R)-butan-2-ol 
• 56002-71-2 trimethyl-(1H,1H,7H-dodecafluoroheptyloxy)silane 
• 78-92-2 iso-butanol 
• 56002-69-8 trimethyl-(1H,1H,3H-tetrafluoropropoxy)silane 
• 56002-63-2 trimethyl-(1H,1H,5H-octafluoropentyloxy)silane 
• 104915-79-9 trimethyl-(1H,1H,9H-hexadecafluorononyloxy)silane 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 24769-51-5 sulfurous acid di-sec-butyl ester 

Downstream Products

• 78-86-4 s-butyl chloride 
• 513-48-4 2-butyl iodide 
• 78-76-2 s-butyl bromide 

Relevant academic research and scientific papers

Synthesis and characterization of a bifunctional nanomagnetic solid acid catalyst (Fe3O4@CeO2/SO42?) and investigation of its efficiency in the protection process of alcohols and phenols via hexamethyldisilazane under solvent-free conditions

In this research, Fe3O4@CeO2 (FC) was synthesized using the coprecipitation method and functionalized by an ammonium sulfate solution to achieve a heterogeneous solid acid Fe3O4@CeO2/SO42? (FCA) catalyst. The synthesized bifunctional catalyst was used in the protection process of alcohols and phenols using hexamethyldisilazane (HMDS) at ambient temperature under solvent-free conditions. Due to its excellent magnetic properties, FCA can easily be separated from the reaction mixture and reused several times without significant loss in its catalytic activity. Excellent yield and selectivity, simple separation, low cost, and high recyclability of the nanocatalyst are outstanding advantages of this procedure. The characterization was carried out using different techniques such as Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM).

Preparation of nano silica supported sodium hydrogen sulfate: As an efficient catalyst for the trimethyl, triethyl and t-butyldimethyl silylations of aliphatic and aromatic alcohols in solution and under solvent-free conditions

Nano silica supported sodium hydrogen sulfate has been prepared by mixing NaHSO4 with activated Nano silicagel. We wish to report a new method for the synthesis of trimethyl (TMS), triethyl (TES) and t-butyldimethyl silyl (TBS) ethers from benzylic, allylic, propargylic alcohols, phenols, naphtholes and some of phenolic drugs in the solution and under solvent-free conditions.

Novel and highly efficient protection of aliphatic alcohols and phenols with hexamethyldisilazane in the presence of La(NO3) 3·6H2O

Aliphatic alcohols and phenols are protected with hexamethyldisilazane in the presence of lanthanum nitrate hexahydrate (La(NO3) 3·6H2O) in excellent yields at room temperature. Taylor & Francis Group, LLC.

Silica sulfate, an efficient catalyst for the trimethylsilylation of alcohols

An easy method for the preparation of trimethylsilyl ethers from alcohols and 1,1,1,3,3,3-hexamethyl-disilazane (HMDS) using silica sulfate as a catalyst under mild conditions in excellent yields is described. Copyright Taylor & Francis Group, LLC.

Phosphomolybdic acid, an efficient catalyst for the trimethylsilylation of alcohols

An easy method for the preparation of trimethylsilyl ethers of alcohols with 1,1,1,3,3,3-hexamethyl- disilazane (HMDS) catalysed by phosphomolybdic acid (PMA) under mild conditions has been carried out in excellent yields.

Silicon-29 NMR spectra of trimethylsilylated alcohols

29Si NMR spectra of trimethylsilyl (TMS) derivatives of 26 simple alcohols were measured under standardized conditions (i.e., in sufficiently diluted deuteriochloroform solutions). Due to association with the solvent the chemical shifts are in almost all cases larger than those reported earlier for different solutions. This observation is in agreement with the proposed mechanism of steric effects as being due to sterically controlled association with the solvent. The use of chloroform as a solvent enhances steric effects hut at the same time it can reduce small differences due to polar effects in closely related compounds. In the studied class of compounds the gross dependence of the chemical shift on polar effects is not substantially affected by the change of the solvent.