182509-19-9

Basic information

• Product Name: (+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID
• Synonyms: (+/-)-trans-N-Boc-4-methyl-pipecolinic acid
• CAS NO: 182509-19-9
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.3
• Mol File: 182509-19-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID(182509-19-9)
• EPA Substance Registry System: (+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID(182509-19-9)

Safety Data

• Hazardous Substances Data: 182509-19-9(Hazardous Substances Data)

Upstream product

• 123811-83-6 (+/-)-cis-Boc-4-methylpipecolinic acid 
• 123387-50-8 4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 626-58-4 4-methylpiperidin 
• 173369-02-3 (N-(tert-butoxycarbonyl)-(2R,4R)-4-methylpiperidine-2-yl)methanol 
• 954378-99-5 ((2S,3S)-3-(2-methylallyl)oxiran-2-yl)methanol 
• 954379-07-8 (N-(tert-butoxycarbonyl)-(6R)-1,2,3,6-tetrahydro-4-methylpyridine-2-yl)methanol 
• 954379-06-7 (2R)-N-allyl-N-(tert-butoxycarbonyl)-2-amino-4-methyl-4-penten-1-ol 
• 123811-73-4 4-Methyl-pyridine-2-carboxylic acid; hydrochloride 
• 1620-76-4 2-Cyano-4-methylpyridin 
• 1003-67-4 4-methylpyridine-1-oxide 
• 124-38-9 carbon dioxide 
• 69081-79-4 (+/-)-cis-4-methylpipecolic acid 

Relevant articles and documents

Substituted piperidine amide derivative, preparation method thereof, and application of derivative to pharmacy

The invention relates to a substituted piperidine amide derivative as shown in a general formula (I) or a stereisomer and pharmaceutically acceptable salt thereof, a preparation method of the derivative, medicinal combination as well as application of the derivative to the aspects of local anaesthesia or analgesia. The definition of each group of the general formula (I) is consistent with that of the description. (The general formula (I) is as shown in the description).

Enantioselective synthesis of trans-4-methylpipecolic acid

(Chemical Equation Presented) An asymmetric synthesis for the preparation of both enantiomers of trans-methylpipecolic acids is described. It is based on Sharpless epoxidation as a chirality source, regioselective ring opening with allylamine, and ring-closing metathesis to construct the piperidine ring. The stereogenic center at C-4 is set by stereoselective hydrogenation that is directed by the alcohol functionality of an intermediate and proceeds with good diastereomeric control (trans/cis 16/1). Crystallization of the Boc-protected amino acid afforded the target products with excellent chemical (98% de) and enantiomeric purity (99% ee).

Direct diastereoselective synthesis of (±)-cis- and (±)-trans-4-methylpipecolic acid and derivatives

(±)-cis- or (±)-trans-4-Methylpipecolic acid and ester derivatives can be obtained directly by addition of electrophiles to α-lithiated N-Boc 4-methylpiperidine.