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182563-08-2

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182563-08-2 Usage

Description

LY 334370 Hydrochloride is a synthetic compound that functions as a 5-HT1F receptor agonist, which is a subtype of serotonin receptors. It has been designed to target and activate specific serotonin receptors, playing a crucial role in modulating various physiological processes.

Uses

Used in Pharmaceutical Industry:
LY 334370 Hydrochloride is used as a therapeutic agent for the potential treatment of migraines. Its agonistic action on the 5-HT1F receptor is believed to alleviate migraine symptoms by modulating the serotonin signaling pathways involved in the onset and progression of migraines. This targeted approach may offer a more effective and specific treatment option for individuals suffering from migraines, potentially reducing the severity and frequency of these debilitating headaches.

Biological Activity

Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.

Check Digit Verification of cas no

The CAS Registry Mumber 182563-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,5,6 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 182563-08:
(8*1)+(7*8)+(6*2)+(5*5)+(4*6)+(3*3)+(2*0)+(1*8)=142
142 % 10 = 2
So 182563-08-2 is a valid CAS Registry Number.

182563-08-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:182563-08-2 SDS

182563-08-2Relevant articles and documents

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

Schmidt, Axel M.,Eilbracht, Peter

, p. 5528 - 5535 (2007/10/03)

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.

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