182563-08-2

Basic information

• Product Name: LY 334370 HYDROCHLORIDE
• Synonyms: LY 334370 HYDROCHLORIDE;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide hydrochloride;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide;BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate;LY-334370 hydrochloride hydrate;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride
• CAS NO: 182563-08-2
• Molecular Formula: C₂₁H₂₂FN₃O
• Molecular Weight: 387.884
• Mol File: 182563-08-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 504.1 °C at 760 mmHg
• Flash Point: 258.7 °C
• Appearance: white to tan/
• Storage Temp.: Store at +4°C
• Solubility: H2O: ≥5mg/mL (warmed)
• CAS DataBase Reference: LY 334370 HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: LY 334370 HYDROCHLORIDE(182563-08-2)
• EPA Substance Registry System: LY 334370 HYDROCHLORIDE(182563-08-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 182563-08-2(Hazardous Substances Data)

Usage

Description

LY 334370 Hydrochloride is a synthetic compound that functions as a 5-HT1F receptor agonist, which is a subtype of serotonin receptors. It has been designed to target and activate specific serotonin receptors, playing a crucial role in modulating various physiological processes.

Uses

Used in Pharmaceutical Industry:
LY 334370 Hydrochloride is used as a therapeutic agent for the potential treatment of migraines. Its agonistic action on the 5-HT1F receptor is believed to alleviate migraine symptoms by modulating the serotonin signaling pathways involved in the onset and progression of migraines. This targeted approach may offer a more effective and specific treatment option for individuals suffering from migraines, potentially reducing the severity and frequency of these debilitating headaches.

Biological Activity

Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 403-43-0 4-fluorobenzoyl chloride 
• 326-03-4 4-fluoro-N-(4-iodophenyl)-benzamide 
• 1445-73-4 1-Methyl-4-piperidone 
• 862158-40-5 N-[4-(4-fluoro-benzoylamino)-phenyl]-hydrazinecarboxylic acid tert-butyl ester 
• 13669-28-8 1-methyl-4-methylene-1-azacyclohexane 
• 201230-82-2 carbon monoxide 

Downstream Products

• 288158-00-9 4-[2-(formamidyl)-5-(4-fluorobenzamidyl)benzoyl]-1-methylpiperidine 

Relevant articles and documents

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.