182563-08-2 Usage
Description
LY 334370 Hydrochloride is a synthetic compound that functions as a 5-HT1F receptor agonist, which is a subtype of serotonin receptors. It has been designed to target and activate specific serotonin receptors, playing a crucial role in modulating various physiological processes.
Uses
Used in Pharmaceutical Industry:
LY 334370 Hydrochloride is used as a therapeutic agent for the potential treatment of migraines. Its agonistic action on the 5-HT1F receptor is believed to alleviate migraine symptoms by modulating the serotonin signaling pathways involved in the onset and progression of migraines. This targeted approach may offer a more effective and specific treatment option for individuals suffering from migraines, potentially reducing the severity and frequency of these debilitating headaches.
Biological Activity
Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
Check Digit Verification of cas no
The CAS Registry Mumber 182563-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,5,6 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 182563-08:
(8*1)+(7*8)+(6*2)+(5*5)+(4*6)+(3*3)+(2*0)+(1*8)=142
142 % 10 = 2
So 182563-08-2 is a valid CAS Registry Number.
182563-08-2Relevant articles and documents
Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis
Schmidt, Axel M.,Eilbracht, Peter
, p. 5528 - 5535 (2007/10/03)
The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.