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18278-29-0

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18278-29-0 Usage

General Description

(1E)-1,5-bis(4-chlorophenyl)penta-1,4-dien-3-one, also known as Clomiphene, is a synthetic nonsteroidal compound that is extensively used as a selective estrogen receptor modulator. It is commonly prescribed for the treatment of infertility in women and is also used in the treatment of polycystic ovary syndrome. It works by increasing the production of certain hormones that are necessary for ovulation. Clomiphene is generally well-tolerated, with mild side effects such as hot flashes, abdominal discomfort, and breast tenderness. However, it may also cause more serious side effects such as ovarian hyperstimulation syndrome, visual disturbances, and multiple births. It is important to use clomiphene under the supervision of a healthcare professional to monitor for any potential complications.

Check Digit Verification of cas no

The CAS Registry Mumber 18278-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,2,7 and 8 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18278-29:
(7*1)+(6*8)+(5*2)+(4*7)+(3*8)+(2*2)+(1*9)=130
130 % 10 = 0
So 18278-29-0 is a valid CAS Registry Number.

18278-29-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (1Z,4E)-1,5-bis(4-chlorophenyl)penta-1,4-dien-3-one

1.2 Other means of identification

Product number -
Other names 1,5-bis-(4-chloro-phenyl)-penta-1,4-dien-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18278-29-0 SDS

18278-29-0Relevant articles and documents

Full Spectroscopic Characterization and Cytotoxicity Activity of Synthetic Dibenzalacetone Derivatives.

de Oliveira, Mauro M.,Nogueira, Carlos E.S.,Almeida-Neto, Francisco Wagner Q.,Santos, Helcio S.,Teixeira, Alexandre M.R.,de Lima-Neto, Pedro,Marinho, Emmanuel S.,de Moraes, Manoel O.,Pessoa, Claudia,Barros-Nepomuceno, Francisco Washington A.

, (2021)

Dibenzalacetone derivatives are organic compounds formed by two α,α′ active sites that provide a large relocation of π-electrons. They have great polarizability that make them excellent chromophore and draw attention for their biological proper

Monofunctional curcumin analogues: evaluation of green and safe developers of latent fingerprints

Pacheco, Bruna S.,Da Silva, Caroline C.,Da Rosa, Bruno N.,Mariotti, Kristiane C.,Nicolodi, Caroline,Poletti, Taís,Segatto, Natália V.,Collares, Tiago,Seixas, Fabiana K.,Paniz, Oscar,Carre?o, Neftali Lenin Vilarreal,Pereira, Claudio M. P.

, p. 3119 - 3129 (2021)

Fingerprint development is one of the most useful techniques in forensic investigation. The powder method is widely used, as it consists of a non-destructive testing. However, some of the powders commonly used are toxic and dangerous to human health. In this sense, monofunctional analogues of curcumin (3a–e) are proposed as novel coloring powders for the development of latent fingerprints. Granulometric and scanning electron microscopy analysis were performed for a better understanding of the interaction between developers and substrates. The best results for the development of fingerprints were obtained with compound (1E,4E)-1,5-di-p-tolylpenta-1,4-dien-3-one (3b). Development with this compound was specific and allowed detection both from male and female donors. Also, in an in vitro experiment, compound 3b presented low cytotoxicity in a mammalian cell line. Based on that, a novel alternative for latent fingerprint developers was proposed.

Synthesis, characterization and antichagasic evaluation of thiosemicarbazones prepared from chalcones and dibenzalacetones

da Silva, Aline Alves,Maia, Pedro Ivo da Silva,Lopes, Carla Duque,de Albuquerque, Sergio,Valle, Marcelo Siqueira

, (2021/02/12)

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (1H and 13C NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 μM) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 μM).

Neuroprotective potential of synthetic mono-carbonyl curcumin analogs assessed by molecular docking studies

Abdulaziz, Osama,Ahmad, Shujaat,Alghamdi, Saad,Almehmadi, Mazen,Ghias, Mehreen,Hussain, Haya,Kamal, Zul,Khan, Farman Ali,Khan, Nasir Mehmood,Muhammad, Juma,Rahman, Shafiq Ur,Shah, Syed Wadood Ali,Ullah, Abid

, (2021/12/04)

Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their prom-ising in vitro anticholinesterase activities, they were further inve

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