18278-29-0

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 67-64-1 acetone 
• 77383-12-1 (E)-4,5-Dibromo-1,5-bis-(4-chloro-phenyl)-pent-1-en-3-one 
• 58168-98-2 1,2,4,5-tetrabromo-1,5-bis-(3-chloro-phenyl)-pentan-3-one 
• 99-91-2 para-chloroacetophenone 
• 3160-40-5 4-(4-chlorophenyl)-3-buten-2-one 
• 67-63-0 isopropyl alcohol 
• 259812-84-5 cis-2,6-bis-(4-chloro-phenyl)-piperidin-4-one 
• 116222-12-9 (2S,6R)-2,6-Bis-(4-chloro-phenyl)-1-methyl-piperidin-4-one 
• 123-54-6 acetylacetone 
• 30626-03-0 (3E)-4-(4-chlorophenyl)-3-buten-2-one 
• 64-19-7 acetic acid 
• 861351-02-2 3,5-dichloro-1,5-bis-(4-chloro-phenyl)-penta-1,3-diene 
• 127-08-2 potassium acetate 

Downstream Products

• 861351-02-2 3,5-dichloro-1,5-bis-(4-chloro-phenyl)-penta-1,3-diene 
• 2256-22-6 5-(4-chloro-phenyl)-3-(4-chloro-styryl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 122228-66-4 bis (4-p-chlorophenyl-2-pyrazolin-3-yl) ketone 
• 115846-78-1 7-(4-Chloro-phenyl)-5-[(E)-2-(4-chloro-phenyl)-vinyl]-3-methyl-1-phenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b][1,4]diazepine 
• 83594-12-1 1,5-bis(4-chlorophenyl)-3-pentanone 
• 916143-52-7 7,11-bis-(4-chloro-phenyl)-2,4-diphenyl-3-thioxo-2,4-diaza-spiro[5.5]undecane-1,5,9-trione 
• 908082-47-3 7,11-bis(4-chlorophenyl)-3-thioxo-2,4-diazaspiro[5.5]undecane-1,5,9-trione 
• 928012-68-4 7,11-Bis-(4-chloro-phenyl)-8,10-bis-[1-phenyl-meth-(Z)-ylidene]-3-thioxo-2,4-diaza-spiro[5.5]undecane-1,5,9-trione 
• 928012-70-8 7,11-Bis-(4-chloro-phenyl)-8,10-bis-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-thioxo-2,4-diaza-spiro[5.5]undecane-1,5,9-trione 
• 928012-71-9 7,11-Bis-(4-chloro-phenyl)-8,10-bis-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-3-thioxo-2,4-diaza-spiro[5.5]undecane-1,5,9-trione 
• 928012-72-0 7,11-Bis-(4-chloro-phenyl)-8,10-bis-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-3-thioxo-2,4-diaza-spiro[5.5]undecane-1,5,9-trione 

Relevant academic research and scientific papers

Full Spectroscopic Characterization and Cytotoxicity Activity of Synthetic Dibenzalacetone Derivatives.

Dibenzalacetone derivatives are organic compounds formed by two α,α′ active sites that provide a large relocation of π-electrons. They have great polarizability that make them excellent chromophore and draw attention for their biological proper

Sulfamic acid: An efficient, cost-effective and green catalyst for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free

Aromatic aldehydes undergo crossed-aldol condensation with ketones in the presence of catalytic amount of sulfamic acid (SA) to afford the corresponding α, β-unsaturated aldol products under solvent-free conditions in good to high yields at 45-80 °C.

Monofunctional curcumin analogues: evaluation of green and safe developers of latent fingerprints

Fingerprint development is one of the most useful techniques in forensic investigation. The powder method is widely used, as it consists of a non-destructive testing. However, some of the powders commonly used are toxic and dangerous to human health. In this sense, monofunctional analogues of curcumin (3a–e) are proposed as novel coloring powders for the development of latent fingerprints. Granulometric and scanning electron microscopy analysis were performed for a better understanding of the interaction between developers and substrates. The best results for the development of fingerprints were obtained with compound (1E,4E)-1,5-di-p-tolylpenta-1,4-dien-3-one (3b). Development with this compound was specific and allowed detection both from male and female donors. Also, in an in vitro experiment, compound 3b presented low cytotoxicity in a mammalian cell line. Based on that, a novel alternative for latent fingerprint developers was proposed.

In vitro and in silico growth inhibitory, anti-ovarian & anti-lung carcinoma effects of 1,5 diarylpenta-1,4-dien-3-one as synthetically modified curcumin analogue

The synthesized 1,5 diarylpenta-1,4-dien-3-one derivatives (compounds 1-6) as synthetic curcumin analogues were tested for their potential anticancer activity against human ovarian and lung adenocarcinoma cells. The absorption, distribution, metabolism, excretion, and toxicity (ADMET/pharmacokinetic) parameters of all the compounds were predicted by admetSAR software. The pharmacokinetics, pharmacodynamics and bioactivity scores properties based on Lipinski rule and Ghose filter, calculated with the help of Molinspiration and ChemDraw. Molecular docking evaluation of all the compounds was also performed by using AutoDock Vina and iGEMDOCK against three most common human anticancer targets; epidermal growth factor receptor (EGFR), heat shock protein (Hsp 90-α), and vascular endothelial growth factor receptor-2 (VEGFR2). The obtained results were compared with the reference compound 7 and drugs 8-10 (7: GO-035; 8: Quinazolin; 9: Naquotinib and 10: Ribofuranuronamide). Finding indicates, all the compounds were potentially interacting with VEGFR2 through the average –9.1 binding energy (BE) with closer contact 1H-NMR). In vitro anti-proliferative activity was tested via MTT method against human ovarian carcinoma (PA-1) and human lung adenocarcinoma (A549) cells and further screened for apoptotic parameters such as nuclear fragmentation and ROS generation. Compound 4 exhibits good dose-dependent anti-proliferative activity (IC50 73 and 79.7 μM) against human ovarian carcinoma and human lung adenocarcinoma, respectively. Communicated by Ramaswamy H. Sarma.

Synthesis, characterization and antichagasic evaluation of thiosemicarbazones prepared from chalcones and dibenzalacetones

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (1H and 13C NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 μM) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 μM).

Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells

This article described the synthesis and biological investigation of a series of symmetric diarylpentanoids, characterized by a dienone moiety and by a different pattern of substitution on the two phenyl rings. The series of compounds 1a–p were tested aga

Neuroprotective potential of synthetic mono-carbonyl curcumin analogs assessed by molecular docking studies

Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their prom-ising in vitro anticholinesterase activities, they were further inve

Chalcones and bis-chalcones analogs as DPPH and ABTS radical scavengers

Background: A number of synthetic scaffolds, along with natural products, have been identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted, medicinally distinct class of compounds “chalcones and bis-chalcon

Electrospray ionization tandem mass spectrometry of monoketone curcuminoids

Rationale: Although monoketone curcuminoids (MKCs) have been largely investigated due to their biological activities, data on the gas-phase fragmentation reactions of protonated MKCs under collision-induced dissociation (CID) conditions are still scarce. Here, we combined electrospray ionization tandem mass spectrometry (ESI-MS/MS) data, multiple-stage mass spectrometry (MSn), deuterium exchange experiments, accurate-mass data, and thermochemical data estimated by computational chemistry to elucidate and to rationalize the fragmentation pathways of eleven synthetic MKCs. Methods: The MKCs were synthesized by Claisen-Schmidt condensation under basic (1–9) or acidic (10–11) conditions. ESI-CID-MS/MS analyses and deuterium-exchange experiments were carried out on a triple quadrupole mass spectrometer. MSn analyses on an ion trap mass spectrometer helped to elucidate the fragmentation pathways. Accurate-mass data and thermochemical data, obtained at the B3LYP/6–31+G(d,p) level of theory, were used to support the ion structures. Results: The most intense product ions were the benzyl ions ([C7H2R1R2R3R4R5]+) and the acylium ions ([M + H ? C8H3R1R2R3R4R5]+), which originated directly from the precursor ion as a result of two competitive hydrogen rearrangements. Product ions [M + H – H2O]+ and [M + H ? C6HR1R2R3R4R5]+, which are formed after Nazarov cyclization, were also common to all the analyzed compounds. In addition, ?Br and ?Cl eliminations were diagnostic for the presence of these halogen atoms at the aromatic ring, whereas ?CH3 eliminations were useful to identify the methyl and methoxy groups attached to this same ring. Nazarov cyclization in the gas phase occurred for all the investigated MKCs and did not depend on the presence of the hydroxyl group at the aromatic ring. However, the presence and the position of a hydroxyl group at the aromatic rings played a key role in the Nazarov cyclization mechanism. Conclusions: Our results reinforce some aspects of the fragmentation pathways previously published for 1,5-bis-(2-methoxyphenyl)-1,4-pentadien-3-one and 1,5-bis-(2-hydroxyphenyl)-1,4-pentadien-3-one. The alternative fragmentation mechanism proposed herein can explain the fragmentation of a wider diversity of monoketone curcuminoids.

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.