18278-29-0Relevant articles and documents
Full Spectroscopic Characterization and Cytotoxicity Activity of Synthetic Dibenzalacetone Derivatives.
de Oliveira, Mauro M.,Nogueira, Carlos E.S.,Almeida-Neto, Francisco Wagner Q.,Santos, Helcio S.,Teixeira, Alexandre M.R.,de Lima-Neto, Pedro,Marinho, Emmanuel S.,de Moraes, Manoel O.,Pessoa, Claudia,Barros-Nepomuceno, Francisco Washington A.
, (2021)
Dibenzalacetone derivatives are organic compounds formed by two α,α′ active sites that provide a large relocation of π-electrons. They have great polarizability that make them excellent chromophore and draw attention for their biological proper
Monofunctional curcumin analogues: evaluation of green and safe developers of latent fingerprints
Pacheco, Bruna S.,Da Silva, Caroline C.,Da Rosa, Bruno N.,Mariotti, Kristiane C.,Nicolodi, Caroline,Poletti, Taís,Segatto, Natália V.,Collares, Tiago,Seixas, Fabiana K.,Paniz, Oscar,Carre?o, Neftali Lenin Vilarreal,Pereira, Claudio M. P.
, p. 3119 - 3129 (2021)
Fingerprint development is one of the most useful techniques in forensic investigation. The powder method is widely used, as it consists of a non-destructive testing. However, some of the powders commonly used are toxic and dangerous to human health. In this sense, monofunctional analogues of curcumin (3a–e) are proposed as novel coloring powders for the development of latent fingerprints. Granulometric and scanning electron microscopy analysis were performed for a better understanding of the interaction between developers and substrates. The best results for the development of fingerprints were obtained with compound (1E,4E)-1,5-di-p-tolylpenta-1,4-dien-3-one (3b). Development with this compound was specific and allowed detection both from male and female donors. Also, in an in vitro experiment, compound 3b presented low cytotoxicity in a mammalian cell line. Based on that, a novel alternative for latent fingerprint developers was proposed.
Synthesis, characterization and antichagasic evaluation of thiosemicarbazones prepared from chalcones and dibenzalacetones
da Silva, Aline Alves,Maia, Pedro Ivo da Silva,Lopes, Carla Duque,de Albuquerque, Sergio,Valle, Marcelo Siqueira
, (2021/02/12)
Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (1H and 13C NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 μM) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 μM).
Neuroprotective potential of synthetic mono-carbonyl curcumin analogs assessed by molecular docking studies
Abdulaziz, Osama,Ahmad, Shujaat,Alghamdi, Saad,Almehmadi, Mazen,Ghias, Mehreen,Hussain, Haya,Kamal, Zul,Khan, Farman Ali,Khan, Nasir Mehmood,Muhammad, Juma,Rahman, Shafiq Ur,Shah, Syed Wadood Ali,Ullah, Abid
, (2021/12/04)
Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their prom-ising in vitro anticholinesterase activities, they were further inve