182878-05-3

Upstream product

• 70362-64-0 4-(hydroxymethyl)phenyl isobutyrate 
• 126070-20-0 4-((tert-butyldimethylsilyloxy)methyl)phenol 
• 1352347-92-2 C₁₇H₂₈O₃Si 
• 115255-87-3 4-trimethylsilyloxymethylphenol 
• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 872025-87-1 S-4-(isobutyryloxy)benzyl (Rp)-8-(3-furyl)adenosine-3',5'-cyclic phosphorothioate 
• 1258516-83-4 N-{2-[4-(isopropylcarbonyl-oxy)benzylthio]benzoyl}-β-alaninamide 

Relevant academic research and scientific papers

THIOETHER PRODRUG COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS

Disclosed are inhibitors of retroviral growth of formula (I), that are useful in treatment of retroviral infections such as HIV. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, a method for inactivating a virus, a method for dissociating a metal ion from a zinc finger-containing protein, and a method for inhibiting the transmission of a virus.

Nucleotide and oligonucleotide prodrugs

The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV

Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies

Several pronucleotide analogs of the model anti-HBV dinucleotide 3′-dA-U2′OMe have been synthesized and evaluated for stability, bioreversibility and cytotoxicity. These studies have helped identify potential candidates for further evaluation.