115255-87-3

Basic information

• Product Name: Phenol, 4-[[(trimethylsilyl)oxy]methyl]-
• CAS NO: 115255-87-3
• Molecular Formula: C10H16O2Si
• Molecular Weight: 196.321
• Mol File: 115255-87-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 4-[[(trimethylsilyl)oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-[[(trimethylsilyl)oxy]methyl]-(115255-87-3)
• EPA Substance Registry System: Phenol, 4-[[(trimethylsilyl)oxy]methyl]-(115255-87-3)

Safety Data

• Hazardous Substances Data: 115255-87-3(Hazardous Substances Data)

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 75-77-4 chloro-trimethyl-silane 
• 18401-58-6 4-(trimethylsilyloxymethyl)phenoxytrimethylsilane 

Downstream Products

• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 200801-70-3 RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine 
• 959624-24-9 (2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl)methanol 
• 1333234-72-2 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol (R)-2-acetoxy(phenyl)acetate 
• 182878-05-3 4-(isopropylcarbonyl-oxy)benzyl iodide 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 70362-64-0 4-(hydroxymethyl)phenyl isobutyrate 
• 115287-29-1 Acetic acid 4-trimethylsilanyloxymethyl-phenyl ester 

Relevant articles and documents

Acyloxyaryl prodrugs of oligonucleoside phosphorothioates

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PROCESS FOR THE PREPARATION OF 2 -HYDROXY- 4 -PHENYL -3, 4 -DIHYDRO-2H-CHROMEN- 6 -YL -METHANOL AND (R) - FESO - DEACYL

The present invention regards an improved and industrially advantageous process for the preparation of the 2-hyaroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called "feso chromenyl" and (R)-2-[3-(diisopropylamino)-l- phenylpropyl]-4-(hydroxymethyl)phenol, also called "(R)-feso deacyl", which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine furnarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate "(R)-feso deacyl", called form B.