18293-54-4

Basic information

• Product Name: 1-TRIMETHYLSILYL-1,2,4-TRIAZOLE
• Synonyms: 2,4-Triazole,1-(trimethylsilyl)-1H-1;4-triazole,1-(trimethylsilyl)-1h-2;N-TRIMETHYLSILYL-1,2,4-TRIAZOLE;1-TRIMETHYLSILYL-1,2,4-TRIAZOLE;Trimethylsilyl-1,2,3-triazole;1-Trimethylsilyl-1H-1,2,4-triazole;1H-1,2,4-Triazole, 1-(trimethylsilyl)-;Trimethylsilyl-1,2,4-Triazole
• CAS NO: 18293-54-4
• Molecular Formula: C₅H₁₁N₃Si
• Molecular Weight: 141.25
• EINECS: 242-170-0
• Product Categories: Heterocyclic Building Blocks;Triazoles;Special Silanes;Building Blocks;Chemical Synthesis
• Mol File: 18293-54-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 74 °C12 mm Hg(lit.)
• Flash Point: 8°C
• Appearance: Colorless liquid
• Density: 0.989 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000349mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 1-TRIMETHYLSILYL-1,2,4-TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TRIMETHYLSILYL-1,2,4-TRIAZOLE(18293-54-4)
• EPA Substance Registry System: 1-TRIMETHYLSILYL-1,2,4-TRIAZOLE(18293-54-4)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• F: 10-21
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 18293-54-4(Hazardous Substances Data)

Usage

Chemical Properties

Clear clear liquid

Purification Methods

Fractionally distil it at atmospheric pressure in an inert atmosphere because it is moisture sensitive. [Birkofer et al. Chem Ber 93 2804 1960.] Trimethylsilyl trifluoromethane (trifluoromethyl trimethylsilane, Ruppert’s reagent)

InChI:InChI=1/C9H8Cl2O2/c1-2-8(12)6-3-5(10)4-7(11)9(6)13/h3-4,13H,2H2,1H3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 75-77-4 chloro-trimethyl-silane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 122967-53-7 Ph2B(μ-1,2,4-triazole(-H)2)BPh2 
• 122967-52-6 Me2B(μ-1,2,4-triazole(-H)2)BMe2 
• 2857-97-8 trimethylsilyl bromide 
• 112809-51-5 letrozol 
• 1189748-33-1 [(PCy3)Ag(μ-(1,2,4-triazol-1-yl))]2 
• 14856-75-8 1-phenyl-1-trimethylsilyloxyethane 
• 1198599-46-0 1-amino-3,5-di-(1H-1,2,4-triazol-1-yl)-2,4,6-trinitrobenzene 
• 1198599-36-8 2,4,6-tri-(1H-triazol-1-yl)-1,3,5-trinitrobenzene 
• 1198599-37-9 2,3,4,6-tetra-(1H-triazol-1-yl)-1,3-dinitrobenzene 
• 1198599-45-9 2,4-di-(1H-triazol-1-yl)-1,3,5-trinitrobenzene 
• 18373-83-6 (1,2,4-triazole-1-yl)-2,4,6-trinitrobenzene 
• 13578-51-3 1-(4-toluenesulfonyl)-1H-1,2,4-triazole 
• 126144-60-3 3'-O-trimethylsilyl-5'-O-dimethoxytrityl-thymidine 
• 78347-45-2 1-(1-Methyl-2-phenyl-1-trimethylsilanyloxy-ethyl)-1H-[1,2,4]triazole 

Relevant articles and documents

PROCESS AND INTERMEDIATE OF LETROZOLE

The present invention relates to a process for the preparation of Letrozole involving the use of novel intermediate of Formula I.

N-SULFONYLBENZOTRIAZOLES. PART 2. REACTIONS OF 1,1'-SULFONYLDIBENZOTRIAZOLE AND 1-BENZENESULFONYL-1,2,4-TRIAZOLE WITH ALCOHOLS; A NEW APPROACH TO N-ALKYLBENZOTRIAZOLES AND N-ALKYL-1,2,4-TRIAZOLES

1,1'-Sulfonyldibenzotriazole (3) reacts with sodium alkoxides to give N-alkylbenzotriazoles.With alkanols, benzotriazolium alkyl sulfates are produced. 1-Benzenesulfonyl-1,2,4-triazole with sodium salts of alcohols gives 1-alkyl-1,2,4-triazoles.The mechanisms of these reactions are discussed.

N-(tert-butyldimethylsilyl)imidazole and related heterocycles: 13C nuclear magnetic resonance study and reaction with dimethylsulfoxide

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