182950-95-4

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 118133-69-0 (3S) methyl 3-hydroxy-5-phenylpentanoate 
• 100-39-0 benzyl bromide 
• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 
• 918148-53-5 (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester 
• 129880-16-6 3-hydroxy-5-phenyl-pentanoic acid methyl ester 

Downstream Products

• 587-63-3 7,8-dihydrokawain 
• 182950-96-5 (6S)-6-(2-phenylethyl)dihydropyran-2,4⁽³⁾-dione 

Relevant academic research and scientific papers

Enantioselective synthesis of (+)- and (-)-dihydrokawain

The first asymmetric synthesis of (+)- and (-)-dihydrokawain, an α-dihydropyrone isolated from the roots of Piper mythisticum, is reported. (+)-Dihydrokawain is the natural product and is of S-configuration.

Chemoenzymatic synthesis of enantiomerically enriched kavalactones

Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl 5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good yields. The effect of different lipases in different solvents has been screened using different acylating agents. This protocol has been extended for the preparation of enantiomerically pure biologically important kavalactones.

Synthetic derivatives

This invention features a 5,6-dihydro-2-pyrone compound of formula (I), wherein R1 is H, OH, or C2?C5 alkoxyl; and R2 is 2-phenyl ethyl, 2-phenyl ethenyl, 2-heteroaryl ethyl, or 2-heteroaryl ethenyl; in which th