918148-53-5

Upstream product

• 108-05-4 vinyl acetate 
• 129880-16-6 3-hydroxy-5-phenyl-pentanoic acid methyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 768-56-9 4-Phenylbut-1-ene 
• 64-19-7 acetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 100-39-0 benzyl bromide 
• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 

Downstream Products

• 182950-95-4 (S)-5-hydroxy-3-oxo-7-phenyl-heptanoic acid tert-butyl ester 
• 182950-96-5 (6S)-6-(2-phenylethyl)dihydropyran-2,4⁽³⁾-dione 
• 587-63-3 7,8-dihydrokawain 
• 118133-69-0 (3S) methyl 3-hydroxy-5-phenylpentanoate 

Relevant academic research and scientific papers

Asymmetric Palladium-Catalyzed Oxycarbonylation of Terminal Alkenes: Efficient Access to β-Hydroxy Alkylcarboxylic Acids

A novel PdII-catalyzed enantioselective oxycarbonylation of alkenes has been established. The ligand with an ethyl group at the C-6 position of Pyox plays a significant role in the intermolecular oxypalladation process, leading to high reactivity and excellent enantioselective control. Compared to the conventional methods, the reaction itself features alkenes as easily prepared starting materials, mild and operationally simple reaction conditions, and insensitivities to air and water. Moreover, this method allows for broad alkene substrate scope, excellent regio- and enantioselectivities, scalabilities and a wide array of applications, and provides a useful route for the convenient and straightforward synthesis of chiral β-hydroxy alkylcarboxylic acids/esters.

Preparation method of chiral beta-acyloxycarboxylate compounds

The invention provides a preparation method of chiral beta-acyloxycarboxylate compounds. The preparation method of the chiral beta-acyloxycarboxylate compounds comprises the following step: in a solvent, in the presence of a palladium catalyst, an oxazoline ligand and an oxidizing agent, carrying out an addition reaction on a compound containing a fragment II, a compound containing a fragment III and carbon monoxide (CO) to obtain the compounds containing the fragment I-1 and/or the compounds containing the fragment I-2. The method disclosed by the invention is high in yield, wide in substrate universality, good in functional group compatibility, mild in reaction condition and simple to operate.

Chemoenzymatic synthesis of enantiomerically enriched kavalactones

Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl 5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good yields. The effect of different lipases in different solvents has been screened using different acylating agents. This protocol has been extended for the preparation of enantiomerically pure biologically important kavalactones.