183063-85-6

Upstream product

• 187472-41-9 [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane 
• 71516-48-8 2-((benzyloxy)methyl)-1,3-dioxolane 
• 52057-48-4 diethyl trimethylsilyl phosphate 

Downstream Products

• 187472-44-2 Toluene-4-sulfonic acid 2-[2-benzyloxy-1-(diethoxy-phosphoryl)-ethoxy]-ethyl ester 
• 187472-50-0 {1-[2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 187472-54-4 {1-[2-(6-Amino-purin-9-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 187472-46-4 {1-[2-(2-Amino-6-benzyloxy-purin-9-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

A Simple Synthetic Route to the Preparation of 2-(1-Phosphonoalkoxy)ethyl Derivatives of heterocyclic Bases as Novel Nucleotide Analogs Related to PMEA

Various 1,3-dioxolanes 9 undergo ring-opening in the presence of triesters of phosphoric acid and Lewis acids under formation of 1-(2-hydroxyethoxy)alkanephosphonates 10.These compounds are the key intermediates for the preparation of novel nucleotide analogs 7 and 8 related to 9-(2-phosphonomethoxyethyl)adenine (PMEA).

Synthesis of 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]guanine, 1-[(2-hydroxy-1-phosphonylethoxy)ethyl]cytosine and 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]adenine

The acyclic nucleoside phosphonate analogues, 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]guanine 6, 1-[(2-hydroxy-1-phosphonylethoxy)ethyl]cytosine 7 and 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]adenine 8, have been prepared by the coupling of a tosylate of the