187472-41-9

Basic information

• Product Name: [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane
• Synonyms: [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane
• CAS NO: 187472-41-9
• Molecular Weight: 394.325
• Mol File: 187472-41-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane(187472-41-9)
• EPA Substance Registry System: [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane(187472-41-9)

Safety Data

• Hazardous Substances Data: 187472-41-9(Hazardous Substances Data)

Upstream product

• 60656-87-3 benzyloxyacetoaldehyde 
• 16029-98-4 trimethylsilyl iodide 
• 71516-48-8 2-((benzyloxy)methyl)-1,3-dioxolane 

Downstream Products

• 187472-46-4 {1-[2-(2-Amino-6-benzyloxy-purin-9-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 187472-44-2 Toluene-4-sulfonic acid 2-[2-benzyloxy-1-(diethoxy-phosphoryl)-ethoxy]-ethyl ester 
• 187472-54-4 {1-[2-(6-Amino-purin-9-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 187472-50-0 {1-[2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 183063-85-6 2-(2-benzyloxy-1-diethylphosphonoethoxy)ethanol 
• 1026549-77-8 [2-Benzyloxy-1-(2-trimethylsilanyloxy-ethoxy)-ethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity

Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lewis acid mediated cleavage of 1,3-dioxolanes followed by reaction with dialkyl or trialkyl phosphites. The best preparative yields were achieved under conditions utilizing tin tetrachloride as Lewis acid and triisopropyl phosphite. Attachment of purine bases to dialkyl [(2-hydroxyethoxy)methyl]phosphonates was performed by Mitsunobu reaction. Final α-branched 9-[2-(phosphonomethoxy)ethyl]purines were tested for antiviral, cytostatic and antiparasitic activity, the latter one determined as inhibitory activity towards Plasmodium falciparum enzyme hypoxanthine-guanine-xanthine phosphoribosyltransfesase. In most cases biological activity was only marginal.