187472-54-4

Upstream product

• 1026549-77-8 [2-Benzyloxy-1-(2-trimethylsilanyloxy-ethoxy)-ethyl]-phosphonic acid diethyl ester 
• 66224-66-6 adenine 
• 187472-44-2 Toluene-4-sulfonic acid 2-[2-benzyloxy-1-(diethoxy-phosphoryl)-ethoxy]-ethyl ester 
• 183063-85-6 2-(2-benzyloxy-1-diethylphosphonoethoxy)ethanol 
• 71516-48-8 2-((benzyloxy)methyl)-1,3-dioxolane 
• 187472-41-9 [2-(2-Benzyloxy-1-iodo-ethoxy)-ethoxy]-trimethyl-silane 

Relevant academic research and scientific papers

Synthesis of 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]guanine, 1-[(2-hydroxy-1-phosphonylethoxy)ethyl]cytosine and 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]adenine

The acyclic nucleoside phosphonate analogues, 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]guanine 6, 1-[(2-hydroxy-1-phosphonylethoxy)ethyl]cytosine 7 and 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]adenine 8, have been prepared by the coupling of a tosylate of the

A Simple Synthetic Route to the Preparation of 2-(1-Phosphonoalkoxy)ethyl Derivatives of heterocyclic Bases as Novel Nucleotide Analogs Related to PMEA

Various 1,3-dioxolanes 9 undergo ring-opening in the presence of triesters of phosphoric acid and Lewis acids under formation of 1-(2-hydroxyethoxy)alkanephosphonates 10.These compounds are the key intermediates for the preparation of novel nucleotide analogs 7 and 8 related to 9-(2-phosphonomethoxyethyl)adenine (PMEA).