71516-48-8

Basic information

• Product Name: 2-((benzyloxy)methyl)-1,3-dioxolane
• Synonyms: 2-((benzyloxy)methyl)-1,3-dioxolane
• CAS NO: 71516-48-8
• Molecular Weight: 194.23
• Mol File: 71516-48-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-((benzyloxy)methyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((benzyloxy)methyl)-1,3-dioxolane(71516-48-8)
• EPA Substance Registry System: 2-((benzyloxy)methyl)-1,3-dioxolane(71516-48-8)

Safety Data

• Hazardous Substances Data: 71516-48-8(Hazardous Substances Data)

Upstream product

• 4360-63-8 2-bromomethyl-1,3-dioxolane 
• 20194-18-7 sodium phenyl-methanolate 
• 100-51-6 benzyl alcohol 
• 5694-68-8 2-hydroxymethyl-1,3-dioxolane 
• 100-39-0 benzyl bromide 
• 60656-87-3 benzyloxyacetoaldehyde 
• 107-21-1 ethylene glycol 

Downstream Products

• 183063-85-6 2-(2-benzyloxy-1-diethylphosphonoethoxy)ethanol 
• 71516-44-4 2-(2-(benzyloxy)-1-(6-chloro-9H-purin-9-yl)ethoxy)ethan-1-ol 
• 5694-68-8 2-hydroxymethyl-1,3-dioxolane 
• 110426-23-8 (2S,3S,4R)-1-Benzyloxy-5-((R)-toluene-4-sulfinyl)-pentane-2,3,4-triol 
• 110426-22-7 (2S,3E)-5-benzyloxy-1-(4-methylphenylsulfinyl)-3-penten-2-ol 
• 110426-23-8 (2R,3R,4S)-1-Benzyloxy-5-((R)-toluene-4-sulfinyl)-pentane-2,3,4-triol 
• 110426-22-7 5-benzyloxy-1-(S_R)-(4-methylphenylsulfinyl)-(2R,3E)-penten-2-ol 
• 110426-21-6 (E)-5-Benzyloxy-1-((R)-toluene-4-sulfinyl)-pent-3-en-2-one 
• 70150-60-6 ethyl 2E-4-(benzyloxy)-2-butenoate 
• 187472-46-4 {1-[2-(2-Amino-6-benzyloxy-purin-9-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 187472-44-2 Toluene-4-sulfonic acid 2-[2-benzyloxy-1-(diethoxy-phosphoryl)-ethoxy]-ethyl ester 
• 187472-54-4 {1-[2-(6-Amino-purin-9-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 187472-50-0 {1-[2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-ethoxy]-2-benzyloxy-ethyl}-phosphonic acid diethyl ester 
• 1026549-77-8 [2-Benzyloxy-1-(2-trimethylsilanyloxy-ethoxy)-ethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity

Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lewis acid mediated cleavage of 1,3-dioxolanes followed by reaction with dialkyl or trialkyl phosphites. The best preparative yields were achieved under conditions utilizing tin tetrachloride as Lewis acid and triisopropyl phosphite. Attachment of purine bases to dialkyl [(2-hydroxyethoxy)methyl]phosphonates was performed by Mitsunobu reaction. Final α-branched 9-[2-(phosphonomethoxy)ethyl]purines were tested for antiviral, cytostatic and antiparasitic activity, the latter one determined as inhibitory activity towards Plasmodium falciparum enzyme hypoxanthine-guanine-xanthine phosphoribosyltransfesase. In most cases biological activity was only marginal.

Benzimidazole compound

An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

ASYMMETRIC SYNTHESIS OF POLYHYDROLXYLATED NATURAL PRODUCTS I. EFFICIENT PREPARATION OF L-ARABINITOL

A new approach to sugar synthesis is demonstrated through the synthesis of L-arabinitol.Reduction of allylic β-ketosulfoxides followed by hydroxylation of the double bond in the resulting allylic β-ketosulfoxides are the two important asymmetric steps involved in the process.