183173-58-2

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 183173-54-8 5-bromo-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 
• 20712-12-3 (2-amino-5-bromophenyl)methanol 
• 5344-90-1 2-Aminobenzyl alcohol 
• 183173-49-1 5-bromo-1-trifluoroacetyl-1,3-dihydroindole-2,2-dicarboxylic acid diethyl ester 
• 183173-36-6 N-(4-bromo-2-hydroxymethylphenyl)-2,2,2-trifluoroacetamide 
• 183173-44-6 N-[4-bromo-2-(bromomethyl)phenyl]-2,2,2-trifluoroacetamide 

Downstream Products

• 183173-61-7 1-benzyl-5-bromo-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 
• 183173-63-9 5-bromo-1-phenylacetyl-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 
• 198276-79-8 1-benzenesulfonyl-5-(2-oxopropyl)-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC BETA-ADRENERGIC AGONISTS

The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or prodrugs thereof, depicted below, which are β-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds of the instant invention are selective agonists of β 3-adrenergic receptor. The invention also relates to methods of use for the compounds and to pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals and poultry. The compounds have the formula STR1 wherein R. sup.1, R. sup.2, R 3, R 4, R 5, Y and Z are as defined in the specification.

A synthesis of functionalized indoline 2,2-biscarboxylates

A synthetic approach to a structurally novel series of indoline 2,2-biscarboxylates is described that employs a tandem bis-alkylation strategy to cyclize the indoline heteroring from the bromide 7 and diethyl bromomalonate. The indolines thus prepared may be N-deprotected and further functionalized on the indoline nitrogen.