18322-85-5

Upstream product

• 613-91-2 acetophenone oxime 
• 65-85-0 benzoic acid 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 1236132-62-9 Te-acetophenone oxime benzenecarbotelluroate 

Downstream Products

• 95433-07-1 anti-α--acetophenon-oxim-<4-methoxy-benzoat> 
• 16451-82-4 anti-α-(Dimethylamino)acetophenone oxime 
• 92579-22-1 anti-α-Methylanilino-acetophenon-oxim 
• 95006-05-6 anti-α--acetophenonoxim-benzoat 
• 95432-87-4 syn-α--acetophenon-oxim-benzoat 
• 94872-46-5 anti-α--acetophenon-oxim-<2.4-dinitro-phenylaether> 
• 875537-81-8 syn-α-Brom-acetophenon-oxim-benzoat 

Relevant academic research and scientific papers

Potent inhibitors of lipoprotein-associated phospholipase A2: Benzaldehyde O-heterocycle-4-carbonyloxime

A series of multi-substituted oximes were prepared and their potencies for inhibiting lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were evaluated in vitro. Among them, compounds 3a, 3b, and 3m were identified to display a micromolar potency for inhibiting Lp-PLA2 in whole human plasma and isolated human LDL. Based on these results, structure-activity relationship was studied on modification of three parts of R1, R2, and R3 to identify a potent pharmacophore for Lp-PLA2. In an attempt to introduce various functional groups at R2 and R3, we discovered that replacement of less lipophilic groups led to an increase of inhibitory activity. Among the tested oxime derivatives, cyano- and morpholino-substituted analogue 4f at R2 and R3 had the highest potency with an IC50 value of 0.05 μM in whole human plasma.

A convenient practical synthesis of alkyl and aryl oxime esters

A facile access to the synthesis of alkyl and aryl oxime esters of ketoximes and aldoximes in high yields (90-97%) is reported. The reactions were performed using N-[3-(methylamino)propyl]-N′-ethylcarbodiimide hydrochloride (EDCI) reagent in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst at room temperature. The isolation and purification of products is very simple and in cases where product is solid, column chromatography is avoided. Georg Thieme Verlag Stuttgart New York.

Te-1-acylmethyl and Te-1-iminoalkyl telluroesters: Synthesis and thermolysis leading to 1,3-diketones and O-alkenyl and O-imino esters

A series of Te-1-acylmethyl carbotelluroates was prepared in good isolated yields from the reaction of potassium carbotelluroates with -haloketones in acetonitrile. Thermolysis of the telluroesters afforded vinyl esters in 20-50% yields, while treatment of the carbotellurorates with potassium t-butanolate led to 1,3-diketones in 30-75% yields with the liberation of black tellurium. The reaction of potassium carbotelluroates with -haloaceto oximes gave O-acyl oximes in 50-70% yields via Te-1-iminomethylcarbotelluroates. Copyright Taylor & Francis Group.

(E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors

A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.