183282-02-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 183281-88-1 N⁴-benzoyl-1-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]cytosine 
• 69304-43-4 1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N⁴-benzoylcytosine 
• 169687-75-6 N⁴-benzoyl-1-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]cytosine 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 

Relevant academic research and scientific papers

Probing the MvaI methyltransferase region that interacts with DNA: Affinity labeling with the dialdehyde-containing DNA duplexes

Affinity labeling of methyltransferase MvaI by DNA duplexes containing oxidized 2′-O-β-D-ribofuranosylcytidine or 1-(β-D-galactopyranosyl)thymine residues was performed. Partial chemical hydrolysis of the covalently bound methylase in the conjugates with the dialdehyde-containing DNA allowed us to determine the amino acid region in the C terminus of methylase MvaI that interacts with DNA.

Studies on synthesis and structure of O-β-D- ribofuranosyl(1'→2')ribonucleosides and oligonucleotides

Minor nucleosides found in several eukaryotic initiator tRNAs(i)(Met), O-β-D-ribofuranosyl(1'→2')adenosine and -guanosine (Ar and Gr), as well as their pyrimidine analogues, were obtained from N-protected 3',5'-O-(1,1,3,3- tetraisopropyldisiloxane-1,3-diyl)ribonucleosides and 1-O-acetyl-2,3,5-tri- O-benzoyl-β-D-ribofuranose in the presence of tin tetrachloride in 1,2- dichloroethane. A crystal structure has been solved for 2'-O-ribosyluridine. The 3'-phosphoramidites of protected 2'-O-ribosylribonucleosides were prepared as the reagents for 2'-O-ribofuranosyloligonucleotides synthesis. O- β-D-Ribofuranosyl(1'→2')adenylyl(3'→5')guanosine (ArpG) was obtained and its structure was analyzed by NMR spectroscopy.