18329-78-7

Basic information

• Product Name: 1H-IMIDAZOLE-5-CARBOHYDRAZIDE
• Synonyms: 1H-IMIDAZOLE-5-CARBOHYDRAZIDE;1H-Imidazole-4-carbohydrazide;1H-Imidazole-4-carboxylic acid hydrazide
• CAS NO: 18329-78-7
• Molecular Formula: C₄H₆N₄O
• Molecular Weight: 126.12
• Mol File: 18329-78-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.425g/cm³
• Refractive Index: 1.625
• CAS DataBase Reference: 1H-IMIDAZOLE-5-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMIDAZOLE-5-CARBOHYDRAZIDE(18329-78-7)
• EPA Substance Registry System: 1H-IMIDAZOLE-5-CARBOHYDRAZIDE(18329-78-7)

Safety Data

• Hazardous Substances Data: 18329-78-7(Hazardous Substances Data)

Usage

General Description

1H-Imidazole-5-carbohydrazide is a chemical compound with the molecular formula C4H6N4O, commonly used in organic synthesis and in the preparation of pharmaceuticals and agrochemicals. It is a white, crystalline solid that is soluble in water and has a melting point of 273-274°C. It is also known as hydrazoni-methylimidazol and is used as a building block for the synthesis of various heterocyclic compounds. This chemical has potential applications in the pharmaceutical, agrochemical, and materials industries due to its diverse chemical reactivity and high synthetic versatility. Its main industrial use is as a raw material for the production of other chemicals, particularly in the synthesis of pharmaceutical products.

InChI:InChI=1/C4H6N4O/c5-8-4(9)3-1-6-2-7-3/h1-2H,5H2,(H,6,7)(H,8,9)

Upstream product

• 23785-21-9 1H-imidazole-5-carboxylic acid ethyl ester 
• 23785-21-9 ethyl 1H-imidazole-4-carboxylate 
• 17325-26-7 Methyl imidazole-4-carboxylate 

Relevant articles and documents

Thermal properties and DNA-binding studies of a new kind of acyl hydrazone compounds containing imidazole ring

Three new acyl hydrazone compounds C12H12N 4O3 (I), C12H14N4O 4 (II) and C16H16N4O3 (III) are synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The crystal structural analyses show that the three compounds crystallize in the monoclinic crystal lattice. Their thermal decomposition processes under nitrogen and air are studied by TG-DTG, the sequence of the thermostability for three compounds at each condition is the same: III > I > II. The interaction modes of the three compounds with CT-DNA are investigated by UV-Vis absorption, showing hyperchromic and hypochromic effects. The thermogenic curves of the three compounds reacting with CT-DNA are measured by microcalorimetry, indicating that they are all endothermic reaction and the reaction times are within 10-30 min.

SUBSTITUTED HETEROCYCLES AS BROMODOMAIN INHIBITORS

The present application relates to substituted heterocycles compound of Formula I and pharmaceutical compositions thereof useful for the inhibition of BET protein function by binding to bromodomains (Formula I).