1835-52-5

Usage

Chemical Properties

White powder

InChI:InChI=1/C5H9NO4.ClH/c1-5(9,10)2-3(6)4(7)8;/h6,9-10H,2H2,1H3,(H,7,8);1H/b6-3-;

Upstream product

• 617-45-8 aspartic Acid 
• 67-56-1 methanol 

Downstream Products

• 1093678-96-6 2-(3-fluorobenzamido)-4-methoxy-4-oxobutanoic acid 
• 1093678-92-2 2-(4-tert-butylbenzamido)-4-methoxy-4-oxobutanoic acid 
• 1093678-97-7 2-(3-nitrobenzamido)-4-methoxy-4-oxobutanoic acid 
• 851181-28-7 2-(4-fluorobenzamido)-4-methoxy-4-oxobutanoic acid 
• 108541-05-5 N-benzoylaspartic acid β-methyl ester 
• 4276-08-8 β-methyl N-benzyloxycarbonyl-DL-aspartate 

Relevant academic research and scientific papers

Dynamic Kinetic Resolution of Azlactones by a Chiral N, N-Dimethyl-4-aminopyridine Derivative Containing a 1,1′-Binaphthyl Unit: Importance of Amide Groups

A dynamic kinetic resolution (DKR) of azlactones in the presence of benzoic acid and a binaphthyl-based N,N-4-dimethylaminopyridine (DMAP) derivative 1i having two amide groups at the 3,3′-positions of a binaphthyl unit is developed. The reaction proceeded smoothly with a wide range of azlactones to provide α-amino acid derivatives with good to high enantiomeric ratios (er's). A multigram-scale reaction (2.5 g) for the DKR of azlactone 2d was also demonstrated, and the resulting product was converted to unnatural α-amino acid 6d′.

Asymmetric Amino Acid Synthesis: Preparation of the β Anion derived from Aspartic Acid

(S)-1-t-Butyl 4-methyl N-benzyloxycarbonylaspartate (5a), and (S)-1-t-butyl 4-allyl N-benzyloxycarbonylaspartate (5b) have been synthesized from (S)-aspartic acid (2), and can be readily alkylated and hydroxyalkylated at the β-carbon for asymmetric amino acid synthesis.