1836-27-7

Basic information

• Product Name: 4-bromo-N-hydroxybenzamide
• Synonyms: 4-bromo-N-hydroxybenzamide;UKRORGSYN-BB BBV-065733
• CAS NO: 1836-27-7
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.03
• Mol File: 1836-27-7.mol
• Article Data: 34

Chemical Properties

• Melting Point: 185-186 °C(Solv: ethanol (64-17-5))
• Appearance: /
• Density: 1.701±0.06 g/cm3(Predicted)
• PKA: 8?+-.0.10(Predicted)
• CAS DataBase Reference: 4-bromo-N-hydroxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-N-hydroxybenzamide(1836-27-7)
• EPA Substance Registry System: 4-bromo-N-hydroxybenzamide(1836-27-7)

Safety Data

• Hazardous Substances Data: 1836-27-7(Hazardous Substances Data)

Usage

General Description

4-bromo-N-hydroxybenzamide is a chemical compound with the molecular formula C7H6BrNO2. It is an organic compound that is derived from the substitution of a hydrogen atom by a bromine atom on the benzene ring of N-hydroxybenzamide. 4-bromo-N-hydroxybenzamide is commonly used in organic synthesis and pharmaceutical research as a building block for more complex molecules. 4-bromo-N-hydroxybenzamide is a white to off-white crystalline solid and is known for its ability to form hydrogen bonds with other molecules. It is also known to have anti-inflammatory and antioxidant properties, making it a potential candidate for the development of new drugs.

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 586-76-5 4-Bromobenzoic acid 
• 873-75-6 4-bromobenzenemethanol 
• 82892-00-0 N-(4-bromobenzoyl)imidazole 
• 25062-46-8 4-bromobenzaldehyde oxime 
• 586-75-4 4-chlorobenzoyl chloride 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Downstream Products

• 106-40-1 4-bromo-aniline 
• 64125-02-6 methyl 3-(4-bromophenyl)-5-(2-methoxy-2-oxoethyl)-1,4,2-dioxazole-5-carboxylate 
• 1408231-59-3 C₁₂H₁₄BrNO₄ 
• 2617-78-9 N-(4-bromophenyl)formamide 

Relevant articles and documents

Cu(II)-Catalyzed C-H Amidation/Cyclization of Azomethine Imines with Dioxazolones via Acyl Nitrenes: A Direct Access to Diverse 1,2,4-Triazole Derivatives

We report a Cu(II)-catalyzed C-H amidation/cyclization of azomethine imines with dioxazolones as acyl nitrene transfer reagents under additive-and ligand-free conditions. An array of 1,2,4-triazolo[1,5-a]pyridine derivatives were afforded in moderate to good yields with excellent functional group tolerance. In addition, scale-up reaction and photoluminescence properties were discussed.

P(III)-Assisted Electrochemical Access to Ureas via in situ Generation of Isocyanates from Hydroxamic Acids

An external oxidant-free protocol for the generation of isocyanates from hydroxamic acids assisted by trivalent phosphine under mild electrochemical conditions was reported. The process started with the anodic oxidation of hydroxamic acids, followed by reacting with phosphine to form corresponding alkoxyphosphoniums and subsequent rearrangement with the release of tri-substituted phosphine oxide as the driving force to give isocyanates, which were trapped by N-based nucleophiles to produce various ureas. This method provides a broadly applicable procedure to access isocyanate intermediates under mild electrochemical conditions.

Synthesis of sulfimides and N-Allyl-N-(thio)amides by Ru(II)catalyzed nitrene transfer reactions of N-acyloxyamides

The N-acyloxyamides were employed as effective N-acyl nitrene precursors in reactions with thioethers under the catalysis of a commercially available Ru(II) complex, from which a variety of sulfimides were synthesized efficiently and mildly. If an allyl group is contained in the thioether precursor, the [2,3]-sigmatropic rearrangement of the sulfimide occurs simultaneously and the N-allyl-N-(thio)amides were obtained as the final products. Preliminary mechanistic studies indicated that the Ru-nitrenoid species should be a key intermediate in the transformation.