183612-92-2

Upstream product

• 108-05-4 vinyl acetate 
• 60176-77-4 (1S,4R)-4-hydroxy-2-cyclopentenyl acetate 
• 100-39-0 benzyl bromide 
• 183612-91-1 (+/-)-4-benzyloxy-2-cyclopentenone 
• 59995-47-0 4-Hydroxycyclopent-2-enone 
• 98-00-0 (2-furyl)methyl alcohol 

Downstream Products

• 1146393-41-0 methyl (1S,4R)-4-(benzyloxy)cyclopent-2-ene-1-carboxylate 
• 1146393-30-7 (1S,4R)-4-(benzyloxy)cyclopent-2-en-1-yl benzoate 
• 150338-77-5 (1R,4S)-cis-1-benzyloxycyclopent-2-en-4-ol 

Relevant academic research and scientific papers

ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS

The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

TRIAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS

The present invention provides compounds of Formula (I), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Studies toward the total synthesis of carba analogue of motif C of M. TB cell wall AG complex

Herein we describe the synthesis of the carba analogue of motif C of arabinogalactan complex present in M. tuberculosis cell wall. Pd(0) catalyzed allylic alkylation and Fraser-Reid's glycosidation are the two key reactions that were employed for the synthesis of central glycosyl accepter unit and the glycosylation respectively.

The preparation of optically active 2-cyclopenten-1,4-diol derivatives from furfuryl alcohol

The preparation and enzymatic resolution of several cis-mono-4-O-protected-2-cyclopenten-1,4-diols are described. The process starts with inexpensive furfuryl alcohol and lends itself to the preparation of multigram quantities of various protected, optically active 2-cyclopenten-1,4-diol derivatives. Stereoselective reduction of 4-O-protected-2-cyclopentenone to the cis-mono-O-protected-2-cyclopenten-1,4-diol using LiAlH4/LiI or Red-Al/NaI is described. Subsequent pancreatin-promoted, stereoselective acylation was conducted on these cis-(+/-)-mono-O-protected-cyclopenten-1,4-diols to afford the corresponding alcohols and acetates in moderate to excellent enantioselectivities.