183739-48-2

Upstream product

• 64-18-6 formic acid 
• 183739-47-1 5-amino-1-benzyl-3-(3-chloro-phenylamino)-4-cyano-pyrazole 
• 20570-96-1 benzylhydrazine dihydrochloride 
• 108-42-9 3-chloro-aniline 
• 74906-19-7 2-(((3-chlorophenyl)amino)(methylthio)methylene)malononitrile 

Downstream Products

• 183739-49-3 (1-Benzyl-4-chloro-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-(3-chloro-phenyl)-amine 
• 183739-50-6 1-benzyl-3-(3-chloro-phenylamino)-4-phenylamino-pyrazolo[3,4-d]pyrimidine 
• 183739-53-9 1-benzyl-3-(3-chloro-phenylamino)-4-(3-methyl-phenylamino)-pyrazolo[3,4-d]pyrimidine 
• 183739-52-8 1-benzyl-4-(3-bromo-phenylamino)-3-(3-chloro-phenylamino)-pyrazolo[3,4-d]pyrimidine 
• 183739-51-7 1-benzyl-3,4-di(3-chloro-phenylamino)pyrazolo[3,4-d]pyrimidine 
• 196505-08-5 [1-Benzyl-4-(3-chloro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-(3-chloro-phenyl)-amine 

Relevant academic research and scientific papers

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w