183989-84-6Relevant academic research and scientific papers
PYRROLOPYRIMIDINE AMINES AS COMPLEMENT INHIBITORS
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Page/Page column 343, (2021/10/11)
Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
Acetonitrile-mediated synthesis of 2,4-dichloroquinoline from 2-ethynylaniline and 2,4-dichloroquinazoline from anthranilonitrile
Lee, Jae Hak,Lee, Byoung Se,Shin, Hyunik,Nam, Do Hyun,Chi, Dae Yoon
, p. 65 - 68 (2007/10/03)
2,4-Dichloroquinolines and 2,4-dichloroquinazolines were synthesized from 2-ethynylanilines and anthranilonitriles, respectively, using diphosgene in acetonitrile and heating at 130 °C or 150 °C for 12 hours. This reaction was applied to the synthesis of 4,6-dichloropyrazolo[3,4-d]pyrimidine (dichloro-9H-isopurine). The postulated mechanism is also described. Georg Thieme Verlag Stuttgart.
Synthesis of indoles and quinolones by sequential Wittig and Heck reactions
Latham, Elliot J.,Stanforth, Stephen P.
, p. 2059 - 2063 (2007/10/03)
Trifluoroacetamido derivatives 18a-c and 19a-c react with phosphorane 2 in boiling toluene to give the corresponding enamines 12a-c and 13a-c respectively which are precursors of the trifluoromethylated indoles 14a-c and quinolones 15a-c.
